The LEC Rat pp 335-340 | Cite as

High Expression of Hexokinase Isozyme B During Hepatocarcinogenesis in LEC Rats

  • Sadhana Jain
  • Suresh K. Jain
  • Toshihiro Sugiyama
  • Naoyuki Taniguchi


In rat liver, the phosphorylation of glucose by ATP is catalyzed by two distinct enzymes, glucokinase (GK) and hexokinase (HK). HK has high affinity for glucose (the K m value is below 0.5 mM) and GK has low affinity for glucose (an apparent K m value of 100 mM). The enzyme HK is known to consist of three isozymes (A, B, and C) separable from each other and from GK by starch gel electrophoresis [1–3] and by chromatography on DEAE-cellulose [2, 4, 5]. In normal tissues, the distribution of isozymes of HK is variable and depends upon glucose utilization [5, 6].


Liver Carcinogenesis Hexokinase Isozyme Glucose Phosphorylation Enzyme Advanced Chronic Hepatitis Hereditary Hepatitis 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Sadhana Jain
  • Suresh K. Jain
    • 2
  • Toshihiro Sugiyama
  • Naoyuki Taniguchi
    • 1
  1. 1.Department of BiochemistryOsaka University Medical SchoolSuita, Osaka, 565Japan
  2. 2.Department of Molecular PharmacologyAlbert Einstein College of MedicineBronxUSA

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