High Expression of Hexokinase Isozyme B During Hepatocarcinogenesis in LEC Rats
In rat liver, the phosphorylation of glucose by ATP is catalyzed by two distinct enzymes, glucokinase (GK) and hexokinase (HK). HK has high affinity for glucose (the K m value is below 0.5 mM) and GK has low affinity for glucose (an apparent K m value of 100 mM). The enzyme HK is known to consist of three isozymes (A, B, and C) separable from each other and from GK by starch gel electrophoresis [1–3] and by chromatography on DEAE-cellulose [2, 4, 5]. In normal tissues, the distribution of isozymes of HK is variable and depends upon glucose utilization [5, 6].
KeywordsLiver Carcinogenesis Hexokinase Isozyme Glucose Phosphorylation Enzyme Advanced Chronic Hepatitis Hereditary Hepatitis
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