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The LEC Rat pp 335-340 | Cite as

High Expression of Hexokinase Isozyme B During Hepatocarcinogenesis in LEC Rats

  • Sadhana Jain
  • Suresh K. Jain
  • Toshihiro Sugiyama
  • Naoyuki Taniguchi

Abstract

In rat liver, the phosphorylation of glucose by ATP is catalyzed by two distinct enzymes, glucokinase (GK) and hexokinase (HK). HK has high affinity for glucose (the K m value is below 0.5 mM) and GK has low affinity for glucose (an apparent K m value of 100 mM). The enzyme HK is known to consist of three isozymes (A, B, and C) separable from each other and from GK by starch gel electrophoresis [1–3] and by chromatography on DEAE-cellulose [2, 4, 5]. In normal tissues, the distribution of isozymes of HK is variable and depends upon glucose utilization [5, 6].

Keywords

Liver Carcinogenesis Hexokinase Isozyme Glucose Phosphorylation Enzyme Advanced Chronic Hepatitis Hereditary Hepatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Sadhana Jain
  • Suresh K. Jain
    • 2
  • Toshihiro Sugiyama
  • Naoyuki Taniguchi
    • 1
  1. 1.Department of BiochemistryOsaka University Medical SchoolSuita, Osaka, 565Japan
  2. 2.Department of Molecular PharmacologyAlbert Einstein College of MedicineBronxUSA

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