The LEC Rat pp 328-334 | Cite as

Hepatoma-Associated Alterations of Serum α1-Antitrypsin in LEC Rats

  • Ryuichi Masuda
  • Toshihiro Sugiyama
  • Naoyuki Taniguchi
  • Michihiro C. Yoshida
  • Motomichi Sasaki


LEC rats have been established as a new mutant strain which develops hereditary hepatitis [1–3] and spontaneous hepatocellular carcinomas (hepatomas) [4]. However, the mechanisms of the development of the sequential diseases in LEC rats are not yet known precisely. Hepatic cirrhosis in human infancy or early childhood is known to be associated with alpha1-antitrypsin (α1AT) deficiency [5]. In adults, α1 AT deficiency was described in association with cirrhosis and portal fibrosis of the liver [6–8]. Furthermore, α1AT deficiency showed a high risk for cirrhosis and primary liver cancer [9]. This deficiency indicates an autosomal recessive mode of inheritance [5, 9]. Experimental rat α1AT deficiency produced by galactosamine-treatment was characterized previously [10, 11]. However, the relation between rat α1AT and liver disease has not been reported, although rat α1AT is known to be a glycoprotein which acts as a liver protease inhibitor in plasma and to have several forms produced by sialylation in parental molecules [12–14]. Therefore, our interest was focused on the α1AT of LEC rats which develop hereditary hapatitis and liver cancer. In this study, characteristics of serum α1AT in LEC rats are described.


Sialic Acid Primary Liver Cancer Antitrypsin Deficiency Autosomal Recessive Mode ulAT Molecule 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Ryuichi Masuda
    • 1
  • Toshihiro Sugiyama
    • 2
  • Naoyuki Taniguchi
    • 2
  • Michihiro C. Yoshida
    • 1
  • Motomichi Sasaki
    • 3
  1. 1.Chromosome Research Unit, Faculty of ScienceHokkaido UniversitySapporo, 060Japan
  2. 2.Department of BiochemistryOsaka University Medical SchoolSuita, Osaka, 530Japan
  3. 3.Sasaki Cancer InstituteChiyoda-ku, Tokyo, 101Japan

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