Hepatoma-Associated Alterations of Serum α1-Antitrypsin in LEC Rats
LEC rats have been established as a new mutant strain which develops hereditary hepatitis [1–3] and spontaneous hepatocellular carcinomas (hepatomas) . However, the mechanisms of the development of the sequential diseases in LEC rats are not yet known precisely. Hepatic cirrhosis in human infancy or early childhood is known to be associated with alpha1-antitrypsin (α1AT) deficiency . In adults, α1 AT deficiency was described in association with cirrhosis and portal fibrosis of the liver [6–8]. Furthermore, α1AT deficiency showed a high risk for cirrhosis and primary liver cancer . This deficiency indicates an autosomal recessive mode of inheritance [5, 9]. Experimental rat α1AT deficiency produced by galactosamine-treatment was characterized previously [10, 11]. However, the relation between rat α1AT and liver disease has not been reported, although rat α1AT is known to be a glycoprotein which acts as a liver protease inhibitor in plasma and to have several forms produced by sialylation in parental molecules [12–14]. Therefore, our interest was focused on the α1AT of LEC rats which develop hereditary hapatitis and liver cancer. In this study, characteristics of serum α1AT in LEC rats are described.
KeywordsSialic Acid Primary Liver Cancer Antitrypsin Deficiency Autosomal Recessive Mode ulAT Molecule
Unable to display preview. Download preview PDF.
- 1.Sasaki M, Yoshida MC, Kagami K, Takeichi N, Kobayashi H, Dempo K, Mori M (1985) Spontaneous hepatitis in an inbred strain of Long-Evans rats. Rat News Lett 14:4–6.Google Scholar
- 10.Bolmer S, Kleinerman J (1984) Serum glycoproteins in galactosamine-induced alpha1-antiprotease deficiency. Am Rev Respir Dis 129:A307.Google Scholar
- 17.Dietz AA, Rubinstein HM, Hodges L (1974) Measurement of alpha1-antitrypsin in serum, by immunodiffusion and by enzymatic assay. Clin Chem 20:396–399.Google Scholar
- 20.Makita A, Gasa S, Narita M, Fujita M, Taniguchi N (1983) Alterations of lysosomal hydrolases in human lung cancer. Jpn J Cancer Res 29 (monogram):231–240.Google Scholar