Replicative and Unscheduled DNA Synthesis of LEC Rat Hepatocytes: Relevance to Natural Development of Hepatocellular Carcinoma
The LEC rat is a new mutant inbred strain which suddenly displays coagulative necrosis of hepatocytes at around 4 months after birth , for which a single autosomal recessive gene (hts gene, ) is responsible. Those LEC rats surviving with chronic hepatitis eventually develop hepatocellular carcinomas as they become old [1, 3–5]. Since this hepatitishepatocellular carcinoma sequence is quite similar to the development of human liver cancer, LEC rats are expected to serve as an excellent animal model for the study of human hepatocarcinogenesis.
KeywordsChronic Hepatitis Partial Hepatectomy Human Liver Cancer Excellent Animal Model Human Hepatocarcinogenesis
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