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The LEC Rat pp 320-325 | Cite as

Replicative and Unscheduled DNA Synthesis of LEC Rat Hepatocytes: Relevance to Natural Development of Hepatocellular Carcinoma

  • Norimasa Sawada
  • Hirohumi Sakamoto
  • Hidetoshi Takahashi
  • Katsuhiko Enomoto
  • Yumiko Oyamada
  • Michio Mori

Abstract

The LEC rat is a new mutant inbred strain which suddenly displays coagulative necrosis of hepatocytes at around 4 months after birth [1], for which a single autosomal recessive gene (hts gene, [2]) is responsible. Those LEC rats surviving with chronic hepatitis eventually develop hepatocellular carcinomas as they become old [1, 3–5]. Since this hepatitishepatocellular carcinoma sequence is quite similar to the development of human liver cancer, LEC rats are expected to serve as an excellent animal model for the study of human hepatocarcinogenesis.

Keywords

Chronic Hepatitis Partial Hepatectomy Human Liver Cancer Excellent Animal Model Human Hepatocarcinogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Norimasa Sawada
  • Hirohumi Sakamoto
  • Hidetoshi Takahashi
  • Katsuhiko Enomoto
  • Yumiko Oyamada
  • Michio Mori
    • 1
  1. 1.Department of PathologySapporo Medical CollegeSapporo, 060Japan

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