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The LEC Rat pp 305-312 | Cite as

The Multistep Nature of Spontaneous Liver Cancer Development in the LEC Rat: Analysis of Incidence and Phenotype of Preneoplastic and Neoplastic Liver Lesions

  • Katsuhiko Enomoto
  • Masakuni Sawaki
  • Hidetoshi Takahashi
  • Yasuo Nakajima
  • Kimimaro Dempo
  • Michio Mori

Abstract

The LEC rat has been established and characterized as a new mutant strain which spontaneously develops hepatitis and liver cancer at an extremely high incidence. The LEC rat manifests severe hereditary hepatitis with systemic jaundice and hemorrhagic tendency at around 4 months after birth. About 30%–40% of the rats die during the period of hepatitis because of submassive or massive necrosis of hepatocytes. The remaining rats recover from severe hepatitis and survive more than 1 year. Histopathological examination of the livers of the long-survived LEC rats shows development of preneoplastic and neoplastic lesions at a high incidence with continued hepatocyte death and regeneration (prolonged hepatitis) [1, 2].

Keywords

Liver Lesion Severe Hepatitis Hyperplastic Nodule Liver Carcinogenesis Spontaneous Liver 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Katsuhiko Enomoto
  • Masakuni Sawaki
  • Hidetoshi Takahashi
  • Yasuo Nakajima
  • Kimimaro Dempo
  • Michio Mori
    • 1
  1. 1.Department of PathologySapporo Medical CollegeSapporo, 060Japan

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