The Multistep Nature of Spontaneous Liver Cancer Development in the LEC Rat: Analysis of Incidence and Phenotype of Preneoplastic and Neoplastic Liver Lesions
The LEC rat has been established and characterized as a new mutant strain which spontaneously develops hepatitis and liver cancer at an extremely high incidence. The LEC rat manifests severe hereditary hepatitis with systemic jaundice and hemorrhagic tendency at around 4 months after birth. About 30%–40% of the rats die during the period of hepatitis because of submassive or massive necrosis of hepatocytes. The remaining rats recover from severe hepatitis and survive more than 1 year. Histopathological examination of the livers of the long-survived LEC rats shows development of preneoplastic and neoplastic lesions at a high incidence with continued hepatocyte death and regeneration (prolonged hepatitis) [1, 2].
KeywordsLiver Lesion Severe Hepatitis Hyperplastic Nodule Liver Carcinogenesis Spontaneous Liver
Unable to display preview. Download preview PDF.
- 2.Enomoto K, Takahashi H, Sawaki M, Sawada N, Ikeda T, Hattori A, Mori M (1989) High incidence of spontaneous hepatocellular carcinoma in a new mutant rat of hereditary hepatitis. Proc Am Assoc Cancer Res 30:194.Google Scholar
- 6.Unger H, Adler JH (1978) The histogenesis of hepatoma occurring spontaneously in a strain of sand rats (Psammoncys obesus) Am J Pathol 90:399–410.Google Scholar
- 12.Schulte-Herman R, Timmerman-Trosiener I, Scuppler J (1983) Promotion of spontaneous preneoplastic cells in rat liver as a possible explanation of tumor production by nonmutagenic compounds. Cancer Res 43:830–844.Google Scholar