Neoplastic and Non-Neoplastic Lesions in Aging LEC/Otk Rats
We have previously reported that the SPF-conditioned LEC/Otk rat has characteristic pathological features. (1) Jaundice develops in almost all rats with increase in the plasma glutamic pyruvic transaminase (P-GPT) level. (2) The animals show episodes of jaundice, a high P-GPT level, and liver cell necrosis, but only slight inflammatory cell infiltration. (3) The liver cells show characteristic microvesicular fatty changes. (4) The P-GPT level shows increases, first at 18 weeks and then at 25 weeks of age. (5) The rats show immunological disorders, such as deficiency of immunoglobulins, especially IgG1, and of helper T cells .
KeywordsPituitary Adenoma Primary Biliary Cirrhosis Granulosa Cell Tumor Liver Cell Necrosis Nonneoplastic Lesion
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