Differences in the Course of Hereditary Hepatitis Between Males and Females, and Between Virgins and Parous Female LEC Rats
A strain of Long-Evans rats (LEC), a new autosomal recessive mutant with hepatitis and severe jaundice [1–3], was established at the Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan. The mutant shows a sudden development of jaundice with a high rate of lethality around 4 months of age. The onset of jaundice is characterized by hyperbilirubinemia, elevation of serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) activities, with massive necrosis of hepatocytes. These clinical signs are almost identical with those of human fulminant hepatitis. It is also reported that survivors spontaneously develop liver cancer with time [4–6].
KeywordsParous Female Virgin Female Fulminant Hepatitis Glutamic Pyruvic Transaminase Glutamic Oxaloacetic Trans
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- 1.Sasaki M, Yoshida MC, Kagami K, Takeichi N, Kobayashi H, Dempo K, Mori M (1985) Spontaneous hepatitis in an inbred strain of Long-Evans rats. Rat News Lett: 14:4–6.Google Scholar