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The LEC Rat pp 20-29 | Cite as

Differences in the Course of Hereditary Hepatitis Between Males and Females, and Between Virgins and Parous Female LEC Rats

  • Kazuto Yamazaki
  • Masaaki Nakayama
  • Koji Tomobe
  • Hiroshi Ohyama
  • Yumi Sawada
  • Tsuneo Wakabayashi
  • Noritoshi Takeichi

Abstract

A strain of Long-Evans rats (LEC), a new autosomal recessive mutant with hepatitis and severe jaundice [1–3], was established at the Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan. The mutant shows a sudden development of jaundice with a high rate of lethality around 4 months of age. The onset of jaundice is characterized by hyperbilirubinemia, elevation of serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) activities, with massive necrosis of hepatocytes. These clinical signs are almost identical with those of human fulminant hepatitis. It is also reported that survivors spontaneously develop liver cancer with time [4–6].

Keywords

Parous Female Virgin Female Fulminant Hepatitis Glutamic Pyruvic Transaminase Glutamic Oxaloacetic Trans 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Kazuto Yamazaki
  • Masaaki Nakayama
  • Koji Tomobe
  • Hiroshi Ohyama
  • Yumi Sawada
  • Tsuneo Wakabayashi
    • 1
  • Noritoshi Takeichi
    • 2
  1. 1.Laboratory Animal Research Center, Tsukuba Research LaboratoriesEisai Co., Ltd.TsukubaJapan
  2. 2.Laboratory of Pathology, Cancer InstituteHokkaido University School of MedicineSapporo, 060Japan

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