Drug-Metabolizing Ability and Inducibility of Chromosomal Aberrations and Sister Chromatid Exchanges in LEC Rats Exposed to Cyclophosphamide
The LEC rat strain is a new mutant characterized by the spontaneous development of hepatitis with severe jaundice about 4 months of age [1, 2]. Genetic analysis demonstrated that the disease has an autosomal recessive mode of inheritance, being ruled by a single gene named hts . Although about 30% of rats die of fulminant hepatitis within 1 week after the onset of jaundice, the remaining animals survive with chronic hepatitis for more than 1 year and develop liver cancer .
KeywordsBone Marrow Cell Chromosomal Aberration Aberrant Cell Chromatid Break Autosomal Recessive Mode
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