The LEC Rat pp 261-272 | Cite as

Drug-Metabolizing Ability and Inducibility of Chromosomal Aberrations and Sister Chromatid Exchanges in LEC Rats Exposed to Cyclophosphamide

  • Ryuichi Masuda
  • Syuiti Abe
  • Michihiro C. Yoshida
  • Motomichi Sasaki
  • Toshihiro Sugiyama
  • Naoyuki Taniguchi


The LEC rat strain is a new mutant characterized by the spontaneous development of hepatitis with severe jaundice about 4 months of age [1, 2]. Genetic analysis demonstrated that the disease has an autosomal recessive mode of inheritance, being ruled by a single gene named hts [3]. Although about 30% of rats die of fulminant hepatitis within 1 week after the onset of jaundice, the remaining animals survive with chronic hepatitis for more than 1 year and develop liver cancer [4].


Bone Marrow Cell Chromosomal Aberration Aberrant Cell Chromatid Break Autosomal Recessive Mode 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Ryuichi Masuda
  • Syuiti Abe
  • Michihiro C. Yoshida
    • 1
  • Motomichi Sasaki
    • 2
  • Toshihiro Sugiyama
  • Naoyuki Taniguchi
    • 3
  1. 1.Chromosome Research Unit, Faculty of ScienceHokkaido UniversitySapporo, 060Japan
  2. 2.Sasaki Cancer InstituteChiyoda-ku, Tokyo, 101Japan
  3. 3.Department of BiochemistryOsaka University Medical SchoolSuita, Osaka, 565Japan

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