The LEC Rat pp 244-260 | Cite as

Chromosomal Analysis of Spontaneous Hepatomas, a Derived Cell Line, and Chemically Induced Hepatomas in LEC Rats

  • Ryuichi Masuda
  • Takao Ono
  • Michihiro C. Yoshida
  • Motomichi Sasaki


Recent banding studies of chromosomes in a variety of human and animal tumors have provided a growing body of evidence that certain specific or nonrandom chromosomal changes are causally related to or closely associated with the inhibition, promotion, or progression of malignant neoplasia [1–5]. Despite the vast amount of data now available on nonrandom occurrence of chromosomal abnormalities in human tumors, our knowledge on animal tumors appears to be very limited and the data on hand are rather conflicting.


Bone Marrow Cell Chromosomal Analysis Normal Karyotype Marker Chromosome Abnormal Karyotype 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Ryuichi Masuda
  • Takao Ono
  • Michihiro C. Yoshida
    • 1
  • Motomichi Sasaki
    • 2
  1. 1.Chromosome Research Unit, Faculty of ScienceHokkaido UniversitySapporo, 060Japan
  2. 2.Sasaki Cancer InstituteChiyoda-ku, Tokyo, 101Japan

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