The LEC Rat pp 217-221 | Cite as

Remarkable Reduction of Serum IgG2a Subclass in LEC Rats

  • Yoshitaka Ikeda
  • Toshihiro Sugiyama
  • Naoyuki Taniguchi


Spontaneous hepatitis and hepatoma in LEC rats have been demonstrated as being associated with severe jaundice and immunodeficiency. The immunodeficiency that occurs in LEC rats is characterized by a low level of serum IgG and T-cell dysfunction. Serum IgG levels of the LEC rats remain markedly low after the age of 2 months, although IgM levels are the same as those of the control LEA rats. The spleen and thymus were found to be atrophic before the onset of jaundice [1]. Although the genetic basis has been shown to be a single autosomal recessive mutation, no apparent linkage was observed between at least two genes coding for hepatitis and immunodeficiency [2].


IgG2a Level Serum IgG2a Spontaneous Hepatitis IgG2b Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Namieno T, Takeichi N, Dempo K, Mori MC, Uchino J, Kobayashi H (1989) Combined immunodeficiency in LEC (Long Evans Cinnamon) rats with spontaneous hepatitis (in Japanese). Nippon Geka Gakkai Zasshi 90:886–893.PubMedGoogle Scholar
  2. 2.
    Matsumoto K, Takeichi N, Izumi K, Otsuka H (1989) Quantitative variation in immunoglobulin G (Igsr-1) in LEC rats associated with spontaneous hepatitis and hepatoma. Transplant Proc 21:3259.PubMedGoogle Scholar
  3. 3.
    Bazin H, Beckers A, Querinjean P (1974) Three classes and four (sub)classes of rat immunoglobulins: IgM, IgA, IgE and IgG1, IgG2a, IgG2b, IgG2c. Eur J Immunol 4:44–48.PubMedCrossRefGoogle Scholar
  4. 4.
    Bazin H, Rousseaux J (1979) Rat immunoglobulins. Vet Immunol Immunopathol 1:61–78.PubMedCrossRefGoogle Scholar
  5. 5.
    Rousseaux J, Picque MT, Bazin H, Biserte G (1981) Rat IgG subclasses: Differences in affinity to protein A-sepharose. Mol Immunol 18:639–645.PubMedCrossRefGoogle Scholar
  6. 6.
    Matsumoto K, Ono E, Izumi K, Otsuka H, Yoshida MC, Sasaki M, Takeichi N, Kobayashi H (1987) Expression of new esterases and pathologic profile in LEC rats with spontaneous fulminant hepatitis. Transplant Proc 19:3207–3211.Google Scholar
  7. 7.
    Finkelman FD, Holmes J, Katona IM, Urban JF Jr, Beckmann MP, Park LS, Schooley KA, Coffman RL, Mosmann TR, Paul WE (1990) Lymphokine control of in vivo Immunoglobulin isotype selection. Annu Rev Immunol 8:303–333.PubMedCrossRefGoogle Scholar
  8. 8.
    Esser C, Radbruch A (1990) Immunoglobulin class switching: Molecular and cellular analysis. Annu Rev Immunol 8:717–735.PubMedCrossRefGoogle Scholar
  9. 9.
    McGhee JR, Michalek SM, Ghanta VK (1975) Rat immunoglobulins in serum and secretions: Purification of rat IgM, IgA and IgG and their quantitation in serum, colostrum, milk and saliva. Immunochemistry 12:817–823.PubMedCrossRefGoogle Scholar
  10. 10.
    Vitetta ES, Ohara J, Myers CD, Layton JE, Krammer PH, Paul WE (1985) Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1. J Exp Med 162:1726–1731.PubMedCrossRefGoogle Scholar
  11. 11.
    Snapper CM, Paul WE (1987) Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236:944–947.PubMedCrossRefGoogle Scholar
  12. 12.
    Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) Two types of murine helper T cell clone: 1. Definition according to the profiles of lymphokine activities and secreted proteins. J Immunol 136:2348–2357.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Yoshitaka Ikeda
  • Toshihiro Sugiyama
  • Naoyuki Taniguchi
    • 1
  1. 1.Department of BiochemistryOsaka University Medical SchoolSuita, Osaka, 565Japan

Personalised recommendations