Remarkable Reduction of Serum IgG2a Subclass in LEC Rats
Spontaneous hepatitis and hepatoma in LEC rats have been demonstrated as being associated with severe jaundice and immunodeficiency. The immunodeficiency that occurs in LEC rats is characterized by a low level of serum IgG and T-cell dysfunction. Serum IgG levels of the LEC rats remain markedly low after the age of 2 months, although IgM levels are the same as those of the control LEA rats. The spleen and thymus were found to be atrophic before the onset of jaundice . Although the genetic basis has been shown to be a single autosomal recessive mutation, no apparent linkage was observed between at least two genes coding for hepatitis and immunodeficiency .
KeywordsIgG2a Level Serum IgG2a Spontaneous Hepatitis IgG2b Level
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