Abstract
Spontaneous hepatitis and hepatoma in LEC rats have been demonstrated as being associated with severe jaundice and immunodeficiency. The immunodeficiency that occurs in LEC rats is characterized by a low level of serum IgG and T-cell dysfunction. Serum IgG levels of the LEC rats remain markedly low after the age of 2 months, although IgM levels are the same as those of the control LEA rats. The spleen and thymus were found to be atrophic before the onset of jaundice [1]. Although the genetic basis has been shown to be a single autosomal recessive mutation, no apparent linkage was observed between at least two genes coding for hepatitis and immunodeficiency [2].
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© 1991 Springer-Verlag Tokyo
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Ikeda, Y., Sugiyama, T., Taniguchi, N. (1991). Remarkable Reduction of Serum IgG2a Subclass in LEC Rats. In: Mori, M., Yoshida, M.C., Takeichi, N., Taniguchi, N. (eds) The LEC Rat. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68153-3_24
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DOI: https://doi.org/10.1007/978-4-431-68153-3_24
Publisher Name: Springer, Tokyo
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