The LEC Rat pp 209-216 | Cite as

Genetic Analysis of Immunodeficiency and Hereditary Hepatitis in LEC Rats

  • Atsuo Hattori
  • Yasuhiro Konishi
  • Hiroshi Isomura
  • Kouki Inaoka
  • Yun Zhong
  • Michio Mori


The new mutant LEC rat suffers from hereditary hepatitis with severe jaundice, anemia, subcutaneous bleeding, weight loss, and oliguria at around 4 months after birth [1, 2]. About one-half of the LEC rats die within 1 week after the onset of hepatitis, whereas the remaining LEC rats survive much longer with chronic hepatitis and subsequently develop liver cancer at a high frequency [3, 4].


Thymic Epithelial Cell Abnormal Type Thymic Medulla Autosomal Recessive Gene Reciprocal Backcross 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Atsuo Hattori
  • Yasuhiro Konishi
  • Hiroshi Isomura
  • Kouki Inaoka
  • Yun Zhong
  • Michio Mori
    • 1
  1. 1.Department of PathologySapporo Medical CollegeSapporo, 060Japan

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