Genetic Analysis of Immunodeficiency and Hereditary Hepatitis in LEC Rats
The new mutant LEC rat suffers from hereditary hepatitis with severe jaundice, anemia, subcutaneous bleeding, weight loss, and oliguria at around 4 months after birth [1, 2]. About one-half of the LEC rats die within 1 week after the onset of hepatitis, whereas the remaining LEC rats survive much longer with chronic hepatitis and subsequently develop liver cancer at a high frequency [3, 4].
KeywordsThymic Epithelial Cell Abnormal Type Thymic Medulla Autosomal Recessive Gene Reciprocal Backcross
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