The LEC Rat pp 185-194 | Cite as

Two-DimensionaL Electrophoretic Analysis of Cellular Polypeptides from Livers of LEC Rats

  • Peter J. Wirth
  • Yoshinori Fujimoto
  • Michio Mori
  • Minako Nagao
  • Takashi Sugimura


Cancer development in the liver, and most probably in all other organs and tissues as well, is a multistep process occurring over extended periods of time, and which ultimately leads to the frank development of hepatocellular carcinoma. This process has operationally been divided into the stages of initiation, promotion, and progression although the molecular mechanisms responsible for these stages of carcinogenesis are far from being adequately defined [1, 2]. In man, it is generally accepted that multiple stages, such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma, also exist during the development of liver cancer, especially due to HB virus infection [3]. Although numerous rodent models have been developed for studies on multistage hepatocarcinogenesis induced by chemical carcinogens, attempts to define stages during spontaneous tumor formation in the livers of rats have been few, due to the extremely low natural occurrence of liver tumors in most rat strains [4, 5]. The LEC rat, however, offers a very valuable animal model for such studies, in particular, for defining the relationship between the pathogenesis of hepatitis and hepatocellular carcinogenesis [6–8].


Basic Polypeptide Backcross Animal National Cancer Center Research Institute Spontaneous Tumor Formation Polypeptide Spot 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Peter J. Wirth
    • 1
    • 3
  • Yoshinori Fujimoto
    • 1
    • 3
  • Michio Mori
    • 2
  • Minako Nagao
    • 1
  • Takashi Sugimura
    • 1
  1. 1.Carcinogenesis DivisionNational Cancer Center Research InstituteChuo-ku, Tokyo, 104Japan
  2. 2.Department of PathologySapporo Medical CollegeSapporo, 060Japan
  3. 3.National Cancer Institute, National Institutes of HealthBethesdaUSA

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