The LEC Rat pp 11-19 | Cite as

Reproductive Performance and Effects of Pregnancy on the Acute Phase of Hepatitis in LEC Rats

  • Noriyuki Kasai
  • Eikichi Kamimura
  • Ichiro Miyoshi
  • Michihiro C. Yoshida


LEC rats have been established as a mutant strain that suffers from fulminant hepatitis and severe jaundice at about 4 months of age [1, 2]. The clinical symptoms of hepatitis include severe jaundice, a bleeding tendency, oliguria, loss of body weight, and elevation of the serum levels of bilirubin and hepatic enzymes, such as glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT). About one-half of the animals die within 1 week after the onset of jaundice and, in survivors, hepatocellular carcinoma spontaneously appears after 1 or 1.5 years of age [3]. Recently we described clinico-pathological studies of LEC rats in the acute phase of hepatitis, and made it clear that this phase started 3–4 weeks before the onset of fulminant hepatitis [4]. On the other hand, the sexual maturity of the LEC rat is usually achieved by around the age at which the hepatitis occurs. Therefore, the breeding of LEC rats seems to be highly influenced by a decrease of breeding rate due to the hepatitis.


Sexual Maturity Reproductive Performance Fulminant Hepatitis Glutamic Pyruvic Transaminase Glutamic Oxaloacetic Transaminase 
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  1. 1.
    Sasaki M, Yoshida MC, Kagami K, Takeichi H, Kobayashi K, Dempo K, Mori M, (1989) Spontaneous hepatitis in an inbred strain of Long-Evans rats. Rat News Lett 14:4–6.Google Scholar
  2. 2.
    Yoshida MC, Masuda R, Sasaki M, Takeichi N, Kobayashi H, Dempo K, Mori M, (1988) New mutation causing hereditary hepatitis in the laboratory rat. J Hered 78:361–365.Google Scholar
  3. 3.
    Masuda R, Yoshida MC, Sasaki M, Dempo K, Mori M, (1988) High susceptibility to hepatocellular carcinoma development in LEC rats with hepatitis. Jpn J Cancer Res 79:828–835.PubMedCrossRefGoogle Scholar
  4. 4.
    Kasai N, Osanai T, Miyoshi I, Kamimura E, Yoshida MC, Dempo K, (1990) Clinico-pathological studies of LEC rats with hereditary hepatitis and hepatoma in the acute phase of hepatitis. Lab Anim Sci 40:502–505.PubMedGoogle Scholar
  5. 5.
    Weihe WH (1987) The laboratory rat. In: Poole B (ed) The UFAW handbook on the care and management of laboratory animals. London Scientific and Technical, London, pp 309–330.Google Scholar
  6. 6.
    Eisenfeld AJ, Aten RF, Weinberger M, Haselbacher G, Halpern K (1976) Estrogen receptor in the mammalian liver. Science 191:862–865.PubMedCrossRefGoogle Scholar
  7. 7.
    Eisenfeld AJ, Aten RF (1987) Estrogen receptors and androgen receptors in the mammalian liver. J Steroid Biochem 27:1109–1118.PubMedCrossRefGoogle Scholar
  8. 8.
    Dickson RB, Aten RF, Eisenfeld AJ (1978) An unusual sex steroid binding protein in mature male rat liver cytosol. Endocrinology 103:1636–1646.PubMedCrossRefGoogle Scholar
  9. 9.
    Taya K, Komura H, Watanabe G, Sasamoto S (1989) Peripheral blood levels of immunoreactive inhibin during pseudopregnancy, pregnancy and lactation in the rat. J Endocrinol 121:545–552.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Noriyuki Kasai
    • 1
  • Eikichi Kamimura
    • 2
  • Ichiro Miyoshi
    • 1
  • Michihiro C. Yoshida
    • 3
  1. 1.The Institute for Animal ExperimentationSchool of MedicineJapan
  2. 2.The Center for Experimental Plants and AnimalsJapan
  3. 3.Chromosome Research Unit, Faculty of ScienceHokkaido UniversitySapporo, 060Japan

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