The LEC Rat pp 169-174 | Cite as

Abnormal Lipid Metabolism in LEC Rats

  • Masako Taniguchi
  • Toshihiro Sugiyama
  • Naoyuki Taniguchi


Our previous studies indicated that LEC rats are characterized by a high sensitivity to azacytidine [1], which is a well-known inhibitor of DNA-methyltransferase. In addition, control rats fed choline- and methioninedeficient diets mimic LEC rats, suggesting that the LEC rat has some direct defect in DNA methylation or that the defect is accompanied by a hypomethylated state [2]. Choline deficiency has been reported to induce accumulation of fats in the liver and reduction in circulating phospholipids, triglycerides, and cholesterol in plasma [3–5]. The development of fatty liver in choline-deficient rats could be a result of increased lipid biosynthesis, inhibition of lipid degradation, fatty acid oxidation, or a failure to transfer the newly synthesized triglyceride into the plasma with a resultant increase in liver triglyceride content [5].


Cholesterol Ester Free Fatty Acid Level Choline Deficiency Abnormal Lipid Metabolism Hypomethylated State 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Suzuki K, Sugiyama T, Ookawara T, Kurosawa T, Taniguchi N (to be published) High sensitivity to 5-azacytidine in LEC rats, a strain with a metabolic predisposition to hepatitis and hepatoma: Possible involvement of DNA methylation in the expression of cytochrome P-450 and γ-glutamyl transpeptidase. Biochem Int.Google Scholar
  2. 2.
    Sugiyama T, Matsunaga M, Jain SK, Jain S, Ikeda Y, Taniguchi N (to be published) Enhancing effect of a choline-deficient diet on alterations of hepatic drug-metabolizing enzymes in hepatitis-and hepatoma-predisposed rats (LEC rats) Jap J Cancer Res.Google Scholar
  3. 3.
    Sugiyama K, Mochizuki C, Muramatsu, K (1987) Comparative effects of choline chloride and phosphatidylcholine on plasma and liver lipid levels in rats fed a choline-deficient high cholesterol diet. J Nutr Sci Vitaminol (Tokyo) 33: 369–376.CrossRefGoogle Scholar
  4. 4.
    Mookerjea S, Park CE, Kuksis A (1975) Lipid profiles of plasma lipoproteins of fasted and fed normal and choline-deficient rats. Lipids 10:374–382.PubMedCrossRefGoogle Scholar
  5. 5.
    Aarsaether N, Berge RK, Aarsland A, Svardal A, Ueland PM (1988) Effect of methotrexate on long-chain fatty acid metabolism in liver of rats fed a standard or defined, choline-deficient diet. Biochim Biophys Acta 958:70–80.PubMedGoogle Scholar
  6. 6.
    Taniguchi M, Ishikawa H, Sakagami, T (1986) Phospholipid metabolism in bile duct-ligated rat plasma and erythrocytes. Biochim Biophys Acta 876:631–638.PubMedGoogle Scholar
  7. 7.
    Taniguchi M, Tanabe F, Ishikawa H, Sakagami, T (1983) Experimental biliary obstruction of rat. Initial changes in the structure and lipid content of erythrocytes. Biochim Biophys Acta 753:22–31.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Masako Taniguchi
    • 1
  • Toshihiro Sugiyama
  • Naoyuki Taniguchi
    • 2
  1. 1.Pre-education DepartmentTeikoku Women’s Junior CollegeMoriguchi, 570Japan
  2. 2.Department of BiochemistryOsaka University Medical SchoolSuita, Osaka, 565Japan

Personalised recommendations