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The LEC Rat pp 155-161 | Cite as

LEC Rats Mimic LEA Rats Fed a Choline-Deficient Diet

  • Toshihiro Sugiyama
  • Mikako Matsunaga
  • Yoshitaka Ikeda
  • Naoyuki Taniguchi

Abstract

Previous studies [1, 2] have shown that the composition and the activities of enzymes involved in drug metabolism in LEC rats are quite similar to those observed in hyperplastic foci and nodules induced by chemical carcinogens [3, 4]. Dietary deficiencies of methionine and choline have been shown to enhance the activities of several hepatocarcinogens, and ethionine is known to be both a hepatocarcinogen and an anti-metabolite of methionine. Therefore, we thought choline deficiency and ethionine treatment might provide useful model systems. In the present study, we used immunochemical and biochemical methods to investigate the hepatic enzyme alterations in LEC rats fed a choline-deficient diet or in LEC rats treated with ethionine.

Keywords

Glutamic Oxaloacetic Transaminase Mixed Function Oxidase Choline Deficiency Enzyme Alteration Mixed Function Oxidase Activ 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Sugiyama T, Takeichi N, Kobayashi H, Yoshida MC, Sasaki M, Taniguchi N (1988) Metabolic predisposition of a novel mutant (LEC rats) to hereditary hepatitis and hepatoma: Alterations of the drug metabolizing enzymes. Carcinogenesis 9:1569–1572.PubMedCrossRefGoogle Scholar
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    Sugiyama T, Suzuki K, Ookawara T, Kurosawa T, Taniguchi N (1989) Selective expression and induction of cytochrome P-450PB and P-450MC during the development of hereditary hepatitis and hepatoma of LEC rats. Carcinogenesis 10:2155–2159.PubMedCrossRefGoogle Scholar
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    Cameron R, Sweeney GD, Jones K, Lee G, Farber E (1976) A relative deficiency of cytochrome P-450 and ary hydrocarbon [benzo (a) pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver. Cancer Res 36:3888–3893.PubMedGoogle Scholar
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    Åström A, DePierre JW, Eriksson L (1983) Characterization of drug-metabolizing systems in hyperplastic nodules from the livers of rats receiving 2-acetylaminofluorene in their diet. Carcinogenesis 4:577–581.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Toshihiro Sugiyama
  • Mikako Matsunaga
  • Yoshitaka Ikeda
  • Naoyuki Taniguchi
    • 1
  1. 1.Department of BiochemistryOsaka University Medical SchoolSuita, Osaka, 565Japan

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