The LEC Rat pp 122-132 | Cite as

Abnormal Copper Accumulation in the Liver of LEC Rats: A Rat Form of Wilson’s Disease

  • Yu Li
  • Yuji Togashi
  • Noritoshi Takeichi


Since the hepatitis in LEC rats is controlled by a single autosomal recessive gene [1], a genetic metabolic disorder is likely to be the cause of the hepatitis. Although interesting biochemical changes associated with the development of the hepatitis have been reported [2–4], they have been unable to provide any direct evidence about the pathogenesis of the rats.


Copper Concentration Copper Accumulation Hepatic Copper Bedlington Terrier Abnormal Copper 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Yu Li
    • 1
    • 2
  • Yuji Togashi
  • Noritoshi Takeichi
    • 1
  1. 1.Laboratory of Pathology, Cancer InstituteHokkaido University School of MedicineSapporo, 060Japan
  2. 2.First Department of SurgeryHokkaido University School of MedicineSapporo, 060Japan

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