Advertisement

The LEC Rat pp 103-113 | Cite as

Acute Tubular Necrosis in LEC Rats with Hereditary Hepatic Failure — A New Animal Model of Hepatorenal Syndrome

  • Hiroyuki Tochimaru
  • Yasushi Akutsu
  • Yasushi Nagata
  • Yasuo Takekoshi
  • Shuzo Matsumoto
  • Noritoshi Takeichi

Abstract

It has been reported that LEC rats are a useful animal model for spontaneous fulminant hepatitis [1] and liver cell carcinoma [2]. At 16–20 weeks of age, 80%–90% of LEC rats spontaneously develop severe hepatic disease, but its etiopathogenesis has not yet been clarified. The clinical features of these LEC rats are marked jaundice, ascitis, subcutaneous bleeding, and oliguria, and their low urinary output suggests the presence of an accompanying renal lesion. In this paper, we present the laboratory data and histopathological findings in the liver and kidney of LEC rats — hepatocellular lipid degeneration and acute renal failure due to acute tubular necrosis — and suggest that LEC rats can serve as an animal model for human hepatorenal syndrome.

Keywords

Tubular Epithelial Cell Acute Tubular Necrosis Hepatorenal Syndrome Urinary Sodium Excretion Tubular Basement Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Takeichi N, Kobayashi H, Yoshida MC, Sasaki M, Dempo K, Mori M (1988) Spontaneous hepatitis in Long-Evans rats. Acta Pathol Jpn 38:1369–1375.PubMedGoogle Scholar
  2. 2.
    Masuda R, Yoshida MC, Sasaki M, Dempo K, Mori M (1988) A transplantable cell line derived from spontaneous hepatocellular carcinoma of the hereditary hepatitis LEC rat. Jpn J Cancer Res 79:250–254.PubMedCrossRefGoogle Scholar
  3. 3.
    Epstein M (1988) Hepatorenal syndrome. In: Epstein M (ed) The kidney in liver diseases. Williams and Wilkins, Baltimore p 89.Google Scholar
  4. 4.
    Weinberg AG, Mize CE, Worthen HG (1976) The occurrence of hepatoma in the chronic form of hereditary tyrosinemia. J Pediatr 88:434–438.PubMedCrossRefGoogle Scholar
  5. 5.
    Hovig T, Blomhoff JP, Holme R, Flatmark A, Gjone E (1978) Plasma lipoprotein alerations and morphologic changes with lipid deposition in the kidney of patients with hepatorenal syndrome. Lab Invest 38:540–549.PubMedGoogle Scholar
  6. 6.
    Elsas LJ, Hayslett JP, Spargo BH, Durant JL, Rosengerg LE (1971) Wilson’s disease with reversible renal tubular dysfunction: Correlation with proximal tubular ultra structure. Ann Intern Med 75:427–435.PubMedGoogle Scholar
  7. 7.
    Masuda R, Yoshida MC, Sasaki M, Dempo K, Mori M (1988) Hereditary hepatitis of LEC rats is controlled by autosomal recessive gene. Lab Anim 22:166–172.PubMedCrossRefGoogle Scholar
  8. 8.
    Koppel MH, Coburn JW, Mims MM, Goldstein H, Boyle JD, Rubini ME (1969) Transplantation of cadaveric kidneys from patients with advanced liver disease. N Engl J Med 280:1367–1371.PubMedCrossRefGoogle Scholar
  9. 9.
    Mandel AK, Lansig M, Fahmy A (1982) Acute tubular necrosis in hepatorenal syndrome: An electron microscopy study. Am J Kidney Dis 2:363–374.Google Scholar
  10. 10.
    Solez K (1983) Pathogenesis of acute renal failure. Int Rev Exp Pathol 24: 277–333.PubMedGoogle Scholar
  11. 11.
    Solez K, Racusen LC, Jewell LD (1988) Pathology of acute renal failure occurring in liver disease. In: Epstein M (ed) The Kidney in liver disease. Williams and Willkins, Baltimore, p 182.Google Scholar
  12. 12.
    Wilkinson SP, Hirst D, Day DW, Wiliams R (1976) Spectrum of renal damage in renal failure secondary to cirrhosis and fulminant hepatic failure. J Clin Pathol 31:101–107.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Hiroyuki Tochimaru
  • Yasushi Akutsu
  • Yasushi Nagata
  • Yasuo Takekoshi
  • Shuzo Matsumoto
    • 1
  • Noritoshi Takeichi
    • 2
  1. 1.Department of PediatricsHokkaido UniversitySapporo, 060Japan
  2. 2.Laboratory of Pathology, Cancer Institute, School of MedicineHokkaido UniversitySapporo, 060Japan

Personalised recommendations