The LEC Rat pp 103-113 | Cite as

Acute Tubular Necrosis in LEC Rats with Hereditary Hepatic Failure — A New Animal Model of Hepatorenal Syndrome

  • Hiroyuki Tochimaru
  • Yasushi Akutsu
  • Yasushi Nagata
  • Yasuo Takekoshi
  • Shuzo Matsumoto
  • Noritoshi Takeichi


It has been reported that LEC rats are a useful animal model for spontaneous fulminant hepatitis [1] and liver cell carcinoma [2]. At 16–20 weeks of age, 80%–90% of LEC rats spontaneously develop severe hepatic disease, but its etiopathogenesis has not yet been clarified. The clinical features of these LEC rats are marked jaundice, ascitis, subcutaneous bleeding, and oliguria, and their low urinary output suggests the presence of an accompanying renal lesion. In this paper, we present the laboratory data and histopathological findings in the liver and kidney of LEC rats — hepatocellular lipid degeneration and acute renal failure due to acute tubular necrosis — and suggest that LEC rats can serve as an animal model for human hepatorenal syndrome.


Tubular Epithelial Cell Acute Tubular Necrosis Hepatorenal Syndrome Urinary Sodium Excretion Tubular Basement Membrane 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Hiroyuki Tochimaru
  • Yasushi Akutsu
  • Yasushi Nagata
  • Yasuo Takekoshi
  • Shuzo Matsumoto
    • 1
  • Noritoshi Takeichi
    • 2
  1. 1.Department of PediatricsHokkaido UniversitySapporo, 060Japan
  2. 2.Laboratory of Pathology, Cancer Institute, School of MedicineHokkaido UniversitySapporo, 060Japan

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