Origin of the LEC Strain with a New Mutation Causing Hereditary Hepatitis

  • Michihiro C. Yoshida
  • Motomichi Sasaki
  • Ryuichi Masuda


Over the last 10 years, a large number of animal models for human diseases has been discovered in laboratory mice and rats. Such model animals have become an indispensable tool in many fields of biological and medical research. During the isolating of substrains with different coat colors from non-inbred Long-Evans rats, we established a new mutant LEC strain causing hereditary hepatitis [1, 2]. The clinical signs of hepatitis in LEC rats are similar to human liver disease. Furthermore, liver cancer appears in long-surviving rats after recovery from jaundice. Therefore, LEC rats provide a pertinent model useful for basic and clinical studies of hepatitis and liver cancer, including its experimental therapy, because the treatment and prevention of hepatitis and subsequent liver cancer are current problems of humans. In this introductory chapter, we review the history of the LEC strain.


Coat Color Glutamic Pyruvic Transaminase Glutamic Oxaloacetic Transaminase Severe Jaundice Human Liver Disease 


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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Michihiro C. Yoshida
    • 1
  • Motomichi Sasaki
    • 2
  • Ryuichi Masuda
    • 1
  1. 1.Chromosome Research Unit, Faculty of ScienceHokkaido UniversitySapporo, 060Japan
  2. 2.Sasaki Cancer InstituteChiyoda-ku, Tokyo, 101Japan

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