Gadolinium Neutron Capture Therapy for Brain Tumors—Biological Aspects
The success of Boron Neutron Capture Therapy (B-NCT) has been reported for the last 25 years. . This therapy requires boron to accumulate into neoplastic tissue. Gadolinium (Gd) has been proposed as an another potential nuclide for NCT [2–4] because Gd-157 has an approximately 64-fold greater thermal neutron cross-section (255,000 barns), than does Boron-10, and releases a large total kinetic energy (7.94 MeV) which it shares among prompt γ-rays, internal conversion electrons, and Auger electrons by the thermal neutron capture reaction . Long ranges of high energy γ-rays and electrons deliver doses to infiltrating neoplastic satellite lesions of the main tumor . Additionally, Gd-DTPA, an enhanced material for MR imaging, is clinically available as a tumor-seeking agent. In this study the tumoricidal effect of Gd-NCT was investigated using Gd-DTPA, and its killing effect was confirmed in in vitro and in vivo systems.
KeywordsThermal Neutron Neutron Capture Boron Neutron Capture Therapy Relative Biological Effectiveness Killing Effect
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