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Gadolinium Neutron Capture Therapy for Brain Tumors—Biological Aspects

  • Masao Takagaki
  • Yoshifumi Oda
  • Masato Matsumoto
  • Haruhiko Kikuchi
  • Tooru Kobayashi
  • Keiji Kanda
  • Yowri Ujeno

Abstract

The success of Boron Neutron Capture Therapy (B-NCT) has been reported for the last 25 years. [1]. This therapy requires boron to accumulate into neoplastic tissue. Gadolinium (Gd) has been proposed as an another potential nuclide for NCT [2–4] because Gd-157 has an approximately 64-fold greater thermal neutron cross-section (255,000 barns), than does Boron-10, and releases a large total kinetic energy (7.94 MeV) which it shares among prompt γ-rays, internal conversion electrons, and Auger electrons by the thermal neutron capture reaction [5]. Long ranges of high energy γ-rays and electrons deliver doses to infiltrating neoplastic satellite lesions of the main tumor [3]. Additionally, Gd-DTPA, an enhanced material for MR imaging, is clinically available as a tumor-seeking agent. In this study the tumoricidal effect of Gd-NCT was investigated using Gd-DTPA, and its killing effect was confirmed in in vitro and in vivo systems.

Keywords

Thermal Neutron Neutron Capture Boron Neutron Capture Therapy Relative Biological Effectiveness Killing Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Masao Takagaki
    • 1
  • Yoshifumi Oda
    • 1
  • Masato Matsumoto
    • 1
  • Haruhiko Kikuchi
    • 1
  • Tooru Kobayashi
  • Keiji Kanda
  • Yowri Ujeno
    • 2
  1. 1.Department of Neurosurgery, School of MedicineKyoto UniversityKyoto, 606Japan
  2. 2.Research Reactor Institute of Kyoto UniversityOsakaJapan

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