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Peripheral-Type Benzodiazepine Receptors in Brain Tumors: In Vitro Binding Characteristics and Implication for New Image Analysis

  • Kiyonobu Ikezaki
  • Keith L. Black
  • Kazuo Tabuchi

Abstract

Benzodiazepines are widely used primarily as anticonvulsants, antianxiety drugs, and hypnotics in the central nervous system (CNS). Benzodiazepines bind specifically to their receptors on the plasma membrane of neurons with nanomolar affinity and exert their inhibitory effects on neurons [1,2]. This “central”-type benzodiazepine receptor has been purified, and its cDNA cloned [3]. The central-type benzodiazepine receptor is a macromolecular compex which is closely linked to gamma aminobutylic acid (GABA)A receptors and modulates the GABA-regulated chloride channel in conjunction with the recognition sites of barbiturates, picrotoxin, and bicyclophosphates [4–6].

Keywords

Brain Tumor Single Photon Emission Compute Tomography Isoquinoline Carboxamide Receptor Mapping Image Rodent Brain Tumor Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Kiyonobu Ikezaki
    • 1
  • Keith L. Black
    • 1
  • Kazuo Tabuchi
    • 2
  1. 1.Division of Neurosurgery and Brain Research Institute, School of MedicineUniversity of California at Los AngelesLos AngelesUSA
  2. 2.Department of NeurosurgerySaga Medical SchoolSaga, 849Japan

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