The Extracellular Matrix: Cues from the Microcellular Environment Which Can Inhibit or Facilitate Glioma Cell Growth

  • James T. Rutka


The extracellular matrix (ECM) is the naturally occurring substrate upon which cells migrate, proliferate, and differentiate in vivo [1,2]. The ECM functions as a biological adhesive that maintains the normal cytoarchitecture of different tissues and defines the key spatial relationships among dissimilar cell types. A loss of coordination and an alteration in the interactions between mesenchymal cells and epithelial cells separated by an ECM are thought to fundamental steps in the development and progression by an ECM are thought to fundamental steps in the development and progression of cancer. The interested reader can now refer to a number of key review articles in this field [2–4].


Hyaluronic Acid Glioma Cell Glial Fibrillary Acidic Protein Glioma Cell Line Neural Crest Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • James T. Rutka
    • 1
  1. 1.Hospital for Sick ChildrenUniversity of TorontoTorontoCanada

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