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Effects of CDDP on a Monolayer Cultured 9 L Glioma Cell Line—Evaluation by a FCM Study of a Cellular DNA Histogram

  • Nobutoshi Ryu
  • Shoubu Shibata
  • Akira Ochi
  • Kazuo Mori

Abstract

Cis-diamminedichloroplatinum (CDDP) is known to be an effective drug against many malignant tumors [1,2]. However, in brain tumors, its usefulness is limited because of the blood-brain barrier [3]. To solve this problem, we are investigating the drug delivery system with liposome [4,5]. We have already reported liposome containing CDDP (Lip-CDDP) to be more useful than free-CDDP as a targeting therapy for brain tumors when we studied organ CDDP distribution using 9L-glioma implanted rats [5].

Keywords

Brain Tumor Glioma Cell Antitumoral Effect Propidium Iodide Double Staining Target Brain Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Niijima H (1983) Cis-diamminedichloroplatinum: Its clinical application (in Japanese). Kyouwa-Kikaku-Tsuushin Press, pp 5–6Google Scholar
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    Ochi A, Shibata S, Mori K, Satou T, Sunamoto J (1990) Targeting chemotherapy of brain tumor using liposome-encapsulated cisplatin-Part 2. Pullulan-coated liposomes to target brain tumor. Drug Del Syst 5: 261–265CrossRefGoogle Scholar
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Nobutoshi Ryu
  • Shoubu Shibata
  • Akira Ochi
  • Kazuo Mori
    • 1
  1. 1.Department of NeurosurgeryNagasaki University School of MedicineNagasaki, 852Japan

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