Effects of CDDP on a Monolayer Cultured 9 L Glioma Cell Line—Evaluation by a FCM Study of a Cellular DNA Histogram
Cis-diamminedichloroplatinum (CDDP) is known to be an effective drug against many malignant tumors [1,2]. However, in brain tumors, its usefulness is limited because of the blood-brain barrier . To solve this problem, we are investigating the drug delivery system with liposome [4,5]. We have already reported liposome containing CDDP (Lip-CDDP) to be more useful than free-CDDP as a targeting therapy for brain tumors when we studied organ CDDP distribution using 9L-glioma implanted rats .
KeywordsBrain Tumor Glioma Cell Antitumoral Effect Propidium Iodide Double Staining Target Brain Tumor
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