Effects of CDDP on a Monolayer Cultured 9 L Glioma Cell Line—Evaluation by a FCM Study of a Cellular DNA Histogram

  • Nobutoshi Ryu
  • Shoubu Shibata
  • Akira Ochi
  • Kazuo Mori


Cis-diamminedichloroplatinum (CDDP) is known to be an effective drug against many malignant tumors [1,2]. However, in brain tumors, its usefulness is limited because of the blood-brain barrier [3]. To solve this problem, we are investigating the drug delivery system with liposome [4,5]. We have already reported liposome containing CDDP (Lip-CDDP) to be more useful than free-CDDP as a targeting therapy for brain tumors when we studied organ CDDP distribution using 9L-glioma implanted rats [5].


Brain Tumor Glioma Cell Antitumoral Effect Propidium Iodide Double Staining Target Brain Tumor 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Nobutoshi Ryu
  • Shoubu Shibata
  • Akira Ochi
  • Kazuo Mori
    • 1
  1. 1.Department of NeurosurgeryNagasaki University School of MedicineNagasaki, 852Japan

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