Effects of a Human Monoclonal Antibody and Cytokines on Human Malignant Glioma Cells

  • Hiroshi Takahashi
  • Shozo Nakazawa


We have previously reported that the human monoclonal antibody (MAb) CLN-IgG, which is derived from human uterus cancer lymph node cells, binds strongly to malignant glioma cells and inhibits the tumor growth of gliomas subcutaneously transplanted into nude mice [1]. However, it may be difficult for an antibody to reach all of the tumor cells because of unequal tumor antigen expression within a large tumor mass. Some cytokines have been reported to stimulate the expression of specific membrane surface antigens [2–5]. Accordingly, we performed this study to determine whether the antitumor effect of CLN-IgG on glioma cells was enhanced by cytokines.


Glioma Cell Malignant Glioma Human Monoclonal Antibody Tumor Inoculation Malignant Glioma Cell 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Hiroshi Takahashi
  • Shozo Nakazawa
    • 1
  1. 1.Department of NeurosurgeryNippon Medical SchoolBunkyo-ku, Tokyo, 113Japan

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