Murine Models with Leptomeningeal Dissemination of Human Medulloblastoma Cells
The 5-year survival rate of patients with medulloblastoma has improved as much as 70% in the past 15 years. This dramatic improvement is mainly due to advances in radiotherapy [1–3]. Although medulloblastomas are certainly radiosensitive, they are not always radiocurable because of limited irradiation dosages and adverse effects on the whole neural axis. Sooner or later, tumor regrowth takes place, and the meningeal dissemination of the tumor cells then results in the demise of most patients with medulloblastoma .
KeywordsGlial Fibrillary Acidic Protein Tumor Inoculation Lewis Lung Carcinoma Cell Leptomeningeal Dissemination Human Medulloblastoma
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