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Differentiation of a Medulloblastoma Cell Line Mediated by Protein Kinase A

  • Takashi Kokunai
  • Norihiko Tamaki
  • Satoshi Matsumoto

Abstract

Cyclic AMP has been implicated in the regulation of the growth and differentiation of various normal and malignant cells [1,2]. In neuroblastoma and glioma cells, it has been shown that N6,O2′-dibutyryl cyclic AMP (Bt2-cAMP) induces morphological and biochemical differentiation in vitro [3]. It has been proposed that most, if not all, of the effects of cyclic AMP are mediated by cyclic AMP-dependent protein kinase (protein kinase A). It was also reported that the modulators of protein kinase C system might be induced by differentiation in some neuroblastoma and glioma cells [4,5].

Keywords

Glioma Cell Neuroblastoma Cell Medulloblastoma Cell Human Medulloblastoma Cell Line cAMP Binding Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Takashi Kokunai
  • Norihiko Tamaki
  • Satoshi Matsumoto
    • 1
  1. 1.Department of NeurosurgeryKobe University School of MedicineKobe, 650Japan

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