Differentiation of a Medulloblastoma Cell Line Mediated by Protein Kinase A

  • Takashi Kokunai
  • Norihiko Tamaki
  • Satoshi Matsumoto


Cyclic AMP has been implicated in the regulation of the growth and differentiation of various normal and malignant cells [1,2]. In neuroblastoma and glioma cells, it has been shown that N6,O2′-dibutyryl cyclic AMP (Bt2-cAMP) induces morphological and biochemical differentiation in vitro [3]. It has been proposed that most, if not all, of the effects of cyclic AMP are mediated by cyclic AMP-dependent protein kinase (protein kinase A). It was also reported that the modulators of protein kinase C system might be induced by differentiation in some neuroblastoma and glioma cells [4,5].


Glioma Cell Neuroblastoma Cell Medulloblastoma Cell Human Medulloblastoma Cell Line cAMP Binding Protein 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Takashi Kokunai
  • Norihiko Tamaki
  • Satoshi Matsumoto
    • 1
  1. 1.Department of NeurosurgeryKobe University School of MedicineKobe, 650Japan

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