Effects of Phorbor Esters on Cyclic AMP Accumulation in C6 Glioma Cells
Phorbor esters are well known tumor-promoting agents that directly activate a phospholipid- and calcium-dependent protein kinase C (PKC) [1,2]. It has recently been demonstrated that PKC can influence the (J-adrenergic receptor (BAR) coupling to the cyclic AMP (cAMP)-generating system in a variety of cells and tissues, including mammalian brain. Phorbor 12-myrisate 13-acetate (PMA) enhances the cAMP response to isoproterenol or forskolin in rat brain slices , guinea pig cerebral cortical preparations , rat pinealocytes , and rat cerebral cortical and diencephalic neurons .
KeywordsGlioma Cell cAMP Accumulation cAMP Content Intracellular cAMP Accumulation Cell Surface Signal Transduction
Unable to display preview. Download preview PDF.
- 9.Johnson RA, Toews ML (1989) Protein kinase C activators sensitize cyclic AMP accumulation by intact 1321N1 human astrocytoma cells. Mol Pharmacol 37: 296–303Google Scholar