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Effects of Phorbor Esters on Cyclic AMP Accumulation in C6 Glioma Cells

  • Hirohiko Nakamura
  • Huang Sheng Hao
  • Tetuo Hara
  • Masao Matsutani
  • Kintomo Takakura
  • Nobuyuki Shitara

Abstract

Phorbor esters are well known tumor-promoting agents that directly activate a phospholipid- and calcium-dependent protein kinase C (PKC) [1,2]. It has recently been demonstrated that PKC can influence the (J-adrenergic receptor (BAR) coupling to the cyclic AMP (cAMP)-generating system in a variety of cells and tissues, including mammalian brain. Phorbor 12-myrisate 13-acetate (PMA) enhances the cAMP response to isoproterenol or forskolin in rat brain slices [3], guinea pig cerebral cortical preparations [4], rat pinealocytes [5], and rat cerebral cortical and diencephalic neurons [6].

Keywords

Glioma Cell cAMP Accumulation cAMP Content Intracellular cAMP Accumulation Cell Surface Signal Transduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Hirohiko Nakamura
    • 2
  • Huang Sheng Hao
    • 1
  • Tetuo Hara
    • 1
  • Masao Matsutani
    • 1
  • Kintomo Takakura
    • 1
  • Nobuyuki Shitara
    • 2
  1. 1.Department of NeurosurgeryUniversity of Tokyo HospitalBunkyo-ku, Tokyo, 113Japan
  2. 2.Department of NeurosurgeryKomagome Metropolitan HospitalBunkyo-ku, Tokyo, 113Japan

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