Immunohistochemical Study of Protein Kinase C Isozyme in Recurrent Cases of Malignant Glioma
Protein kinase C (PKC) , an activated phorbol ester known to have a role in promoting carcinogenesis, is likely to be involved in cellular proliferation and in the process of cancer production. In their studies of gliomas, Todo et al.  and Reifenberger et al.  reported that malignant gliomas, e.g., glioblastoma, were immunohistochemically positive for the PKC-type III isozyme. The present immunohistochemical study investigated PKC isozymes in tumor tissues obtained at the first, second, or third operations from 14 cases of glioblastoma and from 4 cases of anaplastic astrocytoma.
KeywordsMalignant Glioma Anaplastic Astrocytoma Recurrent Glioblastoma Glial Fibrillary Acidic Protein Immunoreactivity Acta Neuropath
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