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Immunohistochemical Study of Protein Kinase C Isozyme in Recurrent Cases of Malignant Glioma

  • Osami Kubo
  • Yasuhiko Tajika
  • Masako Katahira
  • Yoshihiro Muragaki
  • Takeko Tajika
  • Hideaki Uchinuno
  • Masae Nitta
  • Mizuo Kagawa

Abstract

Protein kinase C (PKC) [1], an activated phorbol ester known to have a role in promoting carcinogenesis, is likely to be involved in cellular proliferation and in the process of cancer production. In their studies of gliomas, Todo et al. [2] and Reifenberger et al. [3] reported that malignant gliomas, e.g., glioblastoma, were immunohistochemically positive for the PKC-type III isozyme. The present immunohistochemical study investigated PKC isozymes in tumor tissues obtained at the first, second, or third operations from 14 cases of glioblastoma and from 4 cases of anaplastic astrocytoma.

Keywords

Malignant Glioma Anaplastic Astrocytoma Recurrent Glioblastoma Glial Fibrillary Acidic Protein Immunoreactivity Acta Neuropath 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Nishizuka Y (1984) The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 308: 693–698PubMedCrossRefGoogle Scholar
  2. 2.
    Todo T, Sidara N, Takakura K (1989) Immunohistochemical study on the expression of protein kinase C in isozymes (in Japanese). Proceedings of the 2nd annual meeting of the Society for Brain and Immunity, Tokyo, pp 178–182Google Scholar
  3. 3.
    Reifenberger G, Decker M, Wecksler W (1989) Immunohistochemical determination of protein kinase C expression and proliferation activity in human brain tumors. Acta Neuropath 78: 166–175PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Osami Kubo
  • Yasuhiko Tajika
  • Masako Katahira
  • Yoshihiro Muragaki
  • Takeko Tajika
  • Hideaki Uchinuno
  • Masae Nitta
  • Mizuo Kagawa
    • 1
  1. 1.Department of Neurosurgery, Neurological InstituteTokyo Women’s Medical CollegeShinjuku-ku Tokyo, 162Japan

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