Human Malignant Glioma Cells Migrate to Fibronectin and Laminin: Role of Extracellular Matrix Components in Glioma Cell Invasion

  • Takanori Ohnishi
  • Norio Arita
  • Shoju Hiraga
  • Masahide Higuchi
  • Toru Hayakawa


Malignant gliomas are characterized by high invasiveness, which is a major reason for the failure of treatment for these tumors with any mode. At present, the cellular and molecular mechanisms underlying glioma cell invasion are poorly understood. Tumor invasion is a process that consists of sequential events of complex interactions between tumor cells and host tissues. These include adhesion of tumor cells to the extracellular matrix (ECM), degradation of the regional ECM, and tumor cell locomotion [1]. Previous studies have shown that ECM components such as fibronectin (FN) and laminin (LN) not only play an important role in cell adhesion [2], but also promote the directed movement in vitro of various cells, including fibroblasts, neural crest cells, and tumor cells [3–5].


Glioma Cell Glioma Cell Line Neural Crest Cell U373MG Cell Migratory Response 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Takanori Ohnishi
  • Norio Arita
  • Shoju Hiraga
  • Masahide Higuchi
  • Toru Hayakawa
    • 1
  1. 1.Department of NeurosurgeryOsaka University Medical SchoolOsaka, 553Japan

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