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Human Malignant Glioma Cells Migrate to Fibronectin and Laminin: Role of Extracellular Matrix Components in Glioma Cell Invasion

  • Takanori Ohnishi
  • Norio Arita
  • Shoju Hiraga
  • Masahide Higuchi
  • Toru Hayakawa

Abstract

Malignant gliomas are characterized by high invasiveness, which is a major reason for the failure of treatment for these tumors with any mode. At present, the cellular and molecular mechanisms underlying glioma cell invasion are poorly understood. Tumor invasion is a process that consists of sequential events of complex interactions between tumor cells and host tissues. These include adhesion of tumor cells to the extracellular matrix (ECM), degradation of the regional ECM, and tumor cell locomotion [1]. Previous studies have shown that ECM components such as fibronectin (FN) and laminin (LN) not only play an important role in cell adhesion [2], but also promote the directed movement in vitro of various cells, including fibroblasts, neural crest cells, and tumor cells [3–5].

Keywords

Glioma Cell Glioma Cell Line Neural Crest Cell U373MG Cell Migratory Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Liotta LA, Rao CN, Wewer UM (1986) Biochemical interactions of tumor cells with the basement membrane. Ann Rev Biochem 55: 1037–1057PubMedCrossRefGoogle Scholar
  2. 2.
    Terranova VP, Rohrbach DH, Martin GR (1980) Role of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagen. Cell 22: 719–726PubMedCrossRefGoogle Scholar
  3. 3.
    Tsukamoto Y, Helsel WE, Wahl SM (1981) Macrophage production of fibronectin, a chemoattractant for fibroblasts. J Immunol 127: 673–678PubMedGoogle Scholar
  4. 4.
    Bronner-Fraser M (1986) An antibody to a receptor for fibronectin and laminin perturbs cranial neural crest development. Dev Biol 117: 528–536PubMedCrossRefGoogle Scholar
  5. 5.
    Lacovara J, Cramer EB, Quigley JP (1984) Fibronectin enhancement of directed migration of B16 melanoma cells. Cancer Res 44: 1657–1663PubMedGoogle Scholar
  6. 6.
    McComb RD, Bigner DD (1985) Immunolocalization of laminin in neoplasms of the central and peripheral nervous systems. J Neuropathol Exp Neurol 44: 242–253PubMedCrossRefGoogle Scholar
  7. 7.
    Rutka JT, Myatt CA, Giblin JR, Davis RL, Rosenblum ML (1987) Distribution of extracellular matrix proteins in primary human brain tumors: An immuno-histochemical analysis. Can J Neurol Sci 14: 25–30Google Scholar
  8. 8.
    Higuchi M, Ohnishi T, Arita N, Hiraga S, Iwasaki H, Hayakawa T (1991) Immuno-histocemical localization of fibronectin, laminin and fibronectin receptor in human malignant gliomas. No To Shinkei (Brain and Nerve) 43: 17–23Google Scholar
  9. 9.
    Ohnishi T, Arita N, Hayakawa T, Izumoto S, Taki T, Yamamoto H (1990) Motility factor produced by maligant glioma cells: Role in tumor invasion. J Neurosurg 73: 881–888PubMedCrossRefGoogle Scholar
  10. 10.
    Carter SB (1967) Haptotaxis and the mechanism of cell motility. Nature 213: 256–260PubMedCrossRefGoogle Scholar
  11. 11.
    Terranova VP, Liotta LA, Russo RG, Martin GR (1982) Role of laminin in the attachment and metastasis of murine tumor cells. Cancer Res 42: 2265–2269PubMedGoogle Scholar
  12. 12.
    Hynes RO (1987) Integrins: A family of cell surface receptors. Cell 48: 549–554PubMedCrossRefGoogle Scholar
  13. 13.
    Rouslahti E, Pierschbacher MD (1987) New perspectives in cell adhesion: RGD and integrins. Science 238: 491–497CrossRefGoogle Scholar
  14. 14.
    Jokusch BM, Haemmerli G, In Albon A (1983) Cytoskeletal organization in locomoting cells of the V2 rabbit carcinoma. Exp Cell Res 144: 251–263CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Takanori Ohnishi
  • Norio Arita
  • Shoju Hiraga
  • Masahide Higuchi
  • Toru Hayakawa
    • 1
  1. 1.Department of NeurosurgeryOsaka University Medical SchoolOsaka, 553Japan

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