Demonstration of Microtubule-Associated Proteins in Human Gliomas

  • Norihiro Ibayashi
  • Kimirou Nakamura
  • Takashi Houri
  • Satoshi Ueda


Microtubule-associated proteins (MAPs) are one of the major components of microtubules, and their heterogeneity appears to be a characteristic of brain tissue. Various MAPs, including MAP1, 2, 3, 4, 5 and tau, have been isolated from brain tissue. MAP1 and 2 are the major high molecular weight MAPs (Mr. 350,000 and 280,000, respectively). MAP5A (Mr. 320,000) is a subdivision of the MAP1 group which migrates between the prominent MAP1 and MAP2 bands on SDS-polyacrylamide gels. A large number of the MAPs studies have demonstrated the localization of MAPs in the central nervous system and the dynamic changes during their development in the brain [1,2]. However, previous investigations of these MAPs in brain tumors have been restricted exclusively to neuroepithelial tumors showing neuronal differentiation, such as neuroblastoma or medulloblastoma [3,4]. In the present study, we investigated MAPs in human glial tumors and tried to clarify the relationship between morphological anaplasia and the expression of these microtubule proteins in neoplastic glial cells.


Anaplastic Astrocytoma Neuroepithelial Tumor Microtubule Protein Astrocytic Glioma Astrocytic Differentiation 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Norihiro Ibayashi
  • Kimirou Nakamura
  • Takashi Houri
  • Satoshi Ueda
    • 1
  1. 1.Department of NeurosurgeryKyoto Prefectural University of MedicineKyoto, 602Japan

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