Abstract
Microtubule-associated proteins (MAPs) are one of the major components of microtubules, and their heterogeneity appears to be a characteristic of brain tissue. Various MAPs, including MAP1, 2, 3, 4, 5 and tau, have been isolated from brain tissue. MAP1 and 2 are the major high molecular weight MAPs (Mr. 350,000 and 280,000, respectively). MAP5A (Mr. 320,000) is a subdivision of the MAP1 group which migrates between the prominent MAP1 and MAP2 bands on SDS-polyacrylamide gels. A large number of the MAPs studies have demonstrated the localization of MAPs in the central nervous system and the dynamic changes during their development in the brain [1,2]. However, previous investigations of these MAPs in brain tumors have been restricted exclusively to neuroepithelial tumors showing neuronal differentiation, such as neuroblastoma or medulloblastoma [3,4]. In the present study, we investigated MAPs in human glial tumors and tried to clarify the relationship between morphological anaplasia and the expression of these microtubule proteins in neoplastic glial cells.
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© 1991 Springer-Verlag Tokyo
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Ibayashi, N., Nakamura, K., Houri, T., Ueda, S. (1991). Demonstration of Microtubule-Associated Proteins in Human Gliomas. In: Tabuchi, K. (eds) Biological Aspects of Brain Tumors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68150-2_56
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DOI: https://doi.org/10.1007/978-4-431-68150-2_56
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68152-6
Online ISBN: 978-4-431-68150-2
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