Opposite Effects of Cyclic AMP and Cell Density on Expression of αB-Crystallin and Glial Fibrillary Acidic Protein in C-6 Glioma Cells

  • Akiko Iwaki
  • Toru Iwaki
  • Yoshiyuki Sakaki
  • Ronald K. H. Liem
  • James E. Goldman


Crystallins are well known to be water-soluble proteins in the lens that can pack together efficiently to form very large aggregates. α-Crystallin is a heterogeneous aggregate produced by the products of two genes, αA and αB. Of these two genes, αA-crystallin expression seems restricted to the lens [1], In contrast, αB-crystallin is expressed in various extra-ocular tissues such as heart, muscle, kidney, brain, nerve, and placenta [2,3]. The function of αB-crystallin in extra-ocular tissues is not yet known.


Glial Fibrillary Acidic Protein Rosenthal Fiber Involve Protein Kinase Glial Fibrillary Acidic Protein mRNA Glial Fibrillary Acidic Protein Gene 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Akiko Iwaki
    • 1
  • Toru Iwaki
    • 2
  • Yoshiyuki Sakaki
    • 1
  • Ronald K. H. Liem
    • 3
  • James E. Goldman
    • 3
  1. 1.Research Laboratory for Genetic InformationKyushu University 60Fukuoka, 812Japan
  2. 2.Department of Neuropathology, Neurological Institute, Faculty of MedicineKyushu University 60Fukuoka, 812Japan
  3. 3.Department of PathologyColumbia University College of Physicians and SurgeonsNew YorkUSA

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