Genetic Interaction Between Proto-Oncogene and Histocompatibility Antigen Gene Expressions in Cellular Differentiation of Mouse Neuroblastoma

  • Toshiki Yamasaki
  • Kouzo Moritake
  • George Klein


The recognition of major histocompatibility complex (MHC) class I antigens plays an important role in the function of T cells in the immune system both at the regulatory and effector levels [1]. It has been suggested that quantitative variations in target MHC class I expression would reversely influence natural killer cells (NK) compared to T cells [2], and that the MHC expression decreases as a tumor grows [3]. On the other hand, there have been reports on a relationship among N-myc gene expression, cellular differentiation, and tumor progression in neuroblastoma [4,5]. The aim of this study was to examine the interaction of gene regulation between proto-oncogene (N-myc and c-src) and histocompatibility antigen gene expressions, using a dimethyl sulfoxide (DMSO)-induced differentiation model of mouse neuroblastoma.


Major Histocompatibility Complex Mouse Neuroblastoma DMSO Treatment Major Histocompatibility Complex Expression Methyl Sulfoxide 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Zinkernagel RM, Doherty PC (1979) MHC-restricted cytotoxic T-cells: Studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv Immunol 27: 51–77PubMedCrossRefGoogle Scholar
  2. 2.
    Kärre K, Ljunggren HG, Piontek G et al. (1986) Selective rejection of H-2 deficient lymphoma variants suggests alternative immune defense strategy. Nature 319: 675–678PubMedCrossRefGoogle Scholar
  3. 3.
    Bernards R (1987) Suppression of MHC gene expression in cancer cells. TIG 3: 298–301CrossRefGoogle Scholar
  4. 4.
    Schwab M, Ellison J, Busch M et al. (1984) Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to a malignant progression of neuroblastoma. Proc Natl Acad Sci USA 81: 4940–4944PubMedCrossRefGoogle Scholar
  5. 5.
    Ramsay GM, Moscovici G, Moscovici C et al. (1990) Neoplastic transformation and tumorigenesis by the human protooncogene MYC. Proc Natl Acad Sci USA 87: 2102–2106PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Toshiki Yamasaki
    • 1
  • Kouzo Moritake
    • 1
  • George Klein
    • 2
  1. 1.Department of NeurosurgeryShimane Medical UniversityIzuno, 693Japan
  2. 2.Department of Tumor BiologyKarolinska InstituteStockholmSweden

Personalised recommendations