Genetic Interaction Between Proto-Oncogene and Histocompatibility Antigen Gene Expressions in Cellular Differentiation of Mouse Neuroblastoma

  • Toshiki Yamasaki
  • Kouzo Moritake
  • George Klein


The recognition of major histocompatibility complex (MHC) class I antigens plays an important role in the function of T cells in the immune system both at the regulatory and effector levels [1]. It has been suggested that quantitative variations in target MHC class I expression would reversely influence natural killer cells (NK) compared to T cells [2], and that the MHC expression decreases as a tumor grows [3]. On the other hand, there have been reports on a relationship among N-myc gene expression, cellular differentiation, and tumor progression in neuroblastoma [4,5]. The aim of this study was to examine the interaction of gene regulation between proto-oncogene (N-myc and c-src) and histocompatibility antigen gene expressions, using a dimethyl sulfoxide (DMSO)-induced differentiation model of mouse neuroblastoma.


Major Histocompatibility Complex Mouse Neuroblastoma DMSO Treatment Major Histocompatibility Complex Expression Methyl Sulfoxide 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Toshiki Yamasaki
    • 1
  • Kouzo Moritake
    • 1
  • George Klein
    • 2
  1. 1.Department of NeurosurgeryShimane Medical UniversityIzuno, 693Japan
  2. 2.Department of Tumor BiologyKarolinska InstituteStockholmSweden

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