Association of Histocompatibility Antigen Expression with Intracerebral Tumorigenicity
Although the major histocompatibility complex (MHC, H-2 in mouse) class I and class II antigens are either absent or are present only at low levels in the brain, it has been recognized that various kinds of immune reactions may take place within the brain [1–4]. With regard to the immunology of H-2 class I antigen expression, it has been reported that there is a relationship between the level of cell surface H-2 expression and cytotoxic T lymphocyte (CTL) or natural killer cell (NK) susceptibility in certain tumor systems . In the central nervous system, however, little is known about natural resistance mediated by the cytotoxic cellular interaction between T cells and NK cells. Thus, in the present study, we have focused upon examining the immuno-surveillance mechanism for tumor rejection selectively acting in association with MHC class I antigen expression, using a mouse lymphoma system.
KeywordsNatural Killer Natural Killer Cell Syngeneic Mouse Intracerebral Inoculation Thymectomized Mouse
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