Oncogene Expression in High-Grade Astrocytomas: A Comparative Study of Immunogold-Silver and Peroxidase-Antiperoxidase Immunohistochemistry

  • Seiichi Yoshida
  • Ryuichi Tanaka
  • Andrew H. Kaye


The expression products of many oncogenes is known to mediate cell proliferation [1–3], and much interest has been focused upon oncogene expression as a marker for neoplastic phenotypes [4]. Additionally, the level of expression of certain oncogenes in some tumors has been a significant indicator of biological behavior [5]. In this study, we examined the relative efficacy of immunogold silver (IGS) and peroxidase-antiperoxidase (PAP) immunohistochemistry in detecting the expression product of the epidermal growth factor receptor (EGF-R), c-myc, ras, and c-fos in 20 high-grade astrocytomas.


Epidermal Growth Factor Receptor Epidermal Growth Factor Receptor Gene Expression Product Oncogene Expression Neoplastic Phenotype 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Seiichi Yoshida
    • 1
  • Ryuichi Tanaka
    • 1
  • Andrew H. Kaye
    • 2
  1. 1.Department of Neurosurgery, Brain Research InstituteNiigata UniversityNiigata, 951Japan
  2. 2.Department of SurgeryMelbourne UniversityAustralia

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