DNA Aneuploid Cells Showing Discrepancy of Expression Between c-myc Oncogene Products and GFAP in Malignant Glioma

  • Nobuyuki Sakai
  • Keiji Kawamoto
  • Hiroshi Matsumura


There are various reports on brain tumors in the rapidly developing research on oncogenes which have been noted to be associated with human malignant tumors. We have made an analytical study of the cell growth of brain tumors using flow cytometry (FCM), and further evaluated our results by applying simultaneous double staining using anti c-myc or GFAP monoclonal antibodies (MoAb). In the present study we described an interesting finding in the relationship between c-myc oncogene products and DNA content in malignant glioma cells obtained at surgery.


Glioma Cell Double Staining Glioma Cell Line Malignant Glioma Cell Aneuploid Cell 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Nobuyuki Sakai
  • Keiji Kawamoto
  • Hiroshi Matsumura
    • 1
  1. 1.Department of NeurosurgeryKansai Medical UniversityMoriguchi, 570Japan

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