Restriction Fragment Length Polymorphism of the L-myc Gene and Gene Amplification in Meningiomas
Gene amplification is a particular feature of certain human tumors. Epidermal growth factor receptor (EGFR) , c-erbB2 , N-myc , and c-myc  are cellular oncogenes that show gene amplification of human tumor tissues of glial origin. The frequency of EGFR gene amplification is high especially in malignant glioma [1,5]. In human meningioma, however, overexpression of cellular oncogenes  but not gene amplification is described. In order to observe gene ampification in human meningioma, we analyzed genomic deoxyribonucleic acid (DNA) of tumor tissues with Southern blotting .
KeywordsEpidermal Growth Factor Receptor Gene Amplification Malignant Meningioma Epidermal Growth Factor Receptor Kinase Benign Meningioma
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