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Restriction Fragment Length Polymorphism of the L-myc Gene and Gene Amplification in Meningiomas

  • Hideki Kamitani
  • Tomokatsu Hori
  • Satoshi Tanaka
  • Yasuo Hokama
  • Ichiro Okajima
  • Sachio Nomura
  • Kazuko Kawashima
  • Susumu Nishimura

Abstract

Gene amplification is a particular feature of certain human tumors. Epidermal growth factor receptor (EGFR) [1], c-erbB2 [2], N-myc [3], and c-myc [4] are cellular oncogenes that show gene amplification of human tumor tissues of glial origin. The frequency of EGFR gene amplification is high especially in malignant glioma [1,5]. In human meningioma, however, overexpression of cellular oncogenes [6] but not gene amplification is described. In order to observe gene ampification in human meningioma, we analyzed genomic deoxyribonucleic acid (DNA) of tumor tissues with Southern blotting [7].

Keywords

Epidermal Growth Factor Receptor Gene Amplification Malignant Meningioma Epidermal Growth Factor Receptor Kinase Benign Meningioma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Hideki Kamitani
    • 1
  • Tomokatsu Hori
    • 2
  • Satoshi Tanaka
    • 2
  • Yasuo Hokama
    • 1
  • Ichiro Okajima
    • 2
  • Sachio Nomura
    • 3
  • Kazuko Kawashima
    • 3
  • Susumu Nishimura
    • 3
  1. 1.Clinic of NeurosurgeryNojima HospitalKurayoshi, 682Japan
  2. 2.Division of Neurosurgery, Institute of Neurological Sciences, Faculty of MedicineTottori UniversityYonago, 683Japan
  3. 3.Biology DivisionNational Cancer Center Research InstituteChuo-ku, Tokyo, 104Japan

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