Enhanced Expression of the c-myc Oncogenes in Human Brain Tumors

  • Kiyoshi Kazumoto
  • Masahiro Matsumoto
  • Junpei Tamada
  • Ichiro Handa
  • Masaru Tamura
  • Yasuhito Yuasa


Recent advances in molecular biology have provided evidence that the pathological expression of the oncogene is related to cell transformation in vitro and malignancy in vivo [1]. Several oncogenes are activated in different nervous system tumors, e.g., the N-myc gene in neuroblastomas, the c-myc gene [2] and others in malignant gliomas, and the sis and c-myc genes in meningiomas [3], (reviewed in [4]). Furthermore, alterations of the N-myc gene in neuroblastomas are correlated with disease progression and metastasis [5].


Brain Tumor HL60 Cell Southern Blot Hybridization Human Brain Tumor Medulloblastoma Cell 
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  1. 1.
    Marshall C (1985) Human oncogenes. In: Weiss R, Teich N, Varmus H, Coffin J (eds) RNA Tumor Viruses, 2nd edn. Cold Spring Harbor, New York, pp 487–558Google Scholar
  2. 2.
    Trent J, Meitzer P, Rosenblum M. Harsh G, Kinzler K, Mobert R, Feinberg A, Vogelstein B (1986) Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma. Proc Natl Acad Sei USA 83: 470–473Google Scholar
  3. 3.
    Kazumoto K, Tamura M, Hoshino H, Yuasa Y (1990) Enhanced expression of the sis and c-myc oncogenes in human meningiomas. J Neurosurg 72: 786–791PubMedCrossRefGoogle Scholar
  4. 4.
    Tabuchi K (1988) The cell biological characteristics of brain tumors (in Japanese). No Shinkei Geka 16: 919–931PubMedGoogle Scholar
  5. 5.
    Brodeur GH, Seeger RC, Schwab M, Vermus HE, Bishop JM (1984) Amplification of N-myc in untreated human neuroblastomas correlated with advanced disease stage. Science 224: 1121–1124PubMedCrossRefGoogle Scholar
  6. 6.
    Friedman HS, Burger PC, Bigner SH, Trojanowski JQ, Brodeur GM, He X, Wikstrand CJ, Kurtzberg J, Berens ME, Halperin EC, Bigner DD (1988) Phenoty pic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc. Am J Pathol 130: 472–484PubMedGoogle Scholar
  7. 7.
    Hassoun J, Gambarelli D, Grisoli F, Pellet W, Salamon G, Pellissier JF, Toga M (1982) Central neurocytoma. An electron-microscopic study of two cases. Acta Neuropathol (Berl) 52: 151–156CrossRefGoogle Scholar
  8. 8.
    Auffray C, Rougeon F (1980) Purification of mouse immunoglobulin heavy chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem 107: 303–314PubMedCrossRefGoogle Scholar
  9. 9.
    Southern EM (1978) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98: 503–517CrossRefGoogle Scholar
  10. 10.
    Rigby PWJ, Dickmann M, Rhodes C, Berg P (1977) Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase 1. J Mol Biol 113: 237–251PubMedCrossRefGoogle Scholar
  11. 11.
    Blin N, Stafford DW (1976) A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acid Res 3: 2303–2308PubMedGoogle Scholar
  12. 12.
    Hayashi K, Makino R, Sugimura T (1984) Amplification and overexpression of the c-myc gene in Morris hepatomas. Jpn J Cancer Res 75: 475–478Google Scholar
  13. 13.
    Blanchard JM, Piechaczyk M, Dani C, Chambeard JC, Franchi A, Pouyssegur J, Jeanteur P (1985) C-myc gene is transcribed at high rate in Go-arrested fibroblasts and post-transcriptionally regulated in response to growth factors. Nature 317: 443–445PubMedCrossRefGoogle Scholar
  14. 14.
    Land H, Parada F, Weinberg RA (1983) Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304: 596–602PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Kiyoshi Kazumoto
    • 1
  • Masahiro Matsumoto
    • 1
  • Junpei Tamada
    • 1
  • Ichiro Handa
    • 1
  • Masaru Tamura
    • 2
  • Yasuhito Yuasa
    • 3
  1. 1.Department of NeurosurgeryTakasaki National HospitalTakasaki, 370Japan
  2. 2.Department of NeurosurgeryGunma University School of MedicineMaebashi, 371Japan
  3. 3.Department of Hygiene and OncologyTokyo Medical and Dental University School of MedicineBunkyo-ku Tokyo, 113Japan

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