Oncogene Expression in Acoustic Neurinomas

  • Koichi Ichimura
  • Kimiyoshi Hirakawa
  • Atsushi Komatsuzaki
  • Yasuhito Yuasa


Recent molecular biological studies have shown the alterations of several oncogenes in various types of primary intracranial neoplasms, such as glioblastomas [1,2], medulloblastomas [3], and meningiomas [4]. However, such studies concerning the oncogene alteration of intracranial neurinomas have not yet been reported, and it is not clear whether or not an oncogene might be involved in the oncogenesis of neurinomas. In this study, we analyzed the alterations of the c-myc and sis oncogenes in acoustic neurinomas and showed the presence of an enhanced expression of these two oncogenes.


Acoustic Neuroma Oncogene Expression Human Leukemic Cell Line Primary Intracranial Neoplasm Restriction Fragment Length Polymorphism 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Koichi Ichimura
    • 1
    • 3
  • Kimiyoshi Hirakawa
    • 1
  • Atsushi Komatsuzaki
    • 2
  • Yasuhito Yuasa
    • 3
  1. 1.Department of NeurosurgeryTokyo Medical and Dental University School of MedicineBunkyo-Ku, Tokyo, 113Japan
  2. 2.Department of OtorhinolaryngologyTokyo Medical and Dental University School of MedicineBunkyo-Ku, Tokyo, 113Japan
  3. 3.Department of Hygiene and OncologyTokyo Medical and Dental University School of MedicineBunkyo-Ku, Tokyo, 113Japan

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