Abstract
The gene predisposing to retinoblastoma, RB-1, has been mapped to chromo-somal region 13q14 [1], and a cDNA clone has been isolated [2]. Aberrations of this gene have been found not only in retinoblastoma, but also in other human cancers, including osteosarcoma [3], small cell lung cancer [4], and bladder cancer [5]. An epidemiological study revealed that the occurrence of brain tumor in members of a family with hereditary retinoblastoma was more frequent than in normal individuals [6]. This observation suggested the involvement of aberrations of the RB gene in the genesis of brain tumor and prompted us to examine the gene in human brain tumors.
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© 1991 Springer-Verlag Tokyo
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Katahira, M. et al. (1991). Detection of Retinoblastoma Gene Aberrations in Human Brain Tumor by Single-Strand Conformation Polymorphism Analysis of Polymerase Chain Reaction Products. In: Tabuchi, K. (eds) Biological Aspects of Brain Tumors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68150-2_44
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DOI: https://doi.org/10.1007/978-4-431-68150-2_44
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68152-6
Online ISBN: 978-4-431-68150-2
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