Detection of p53 Gene Mutations in Human Brain Tumors by Single-strand Conformation Polymorphism Analysis of Polymerase Chain Reaction Products
The normal (wild-type) p53 product acts as a suppressor of transformation , while mutated p53 proteins may inactivate the wild-type p53 function resulting in cell transformation . Mutations of the p53 gene have been found in conjunction with chromosome 17p allelic deletions in many human tumors [3,4].
KeywordsAnaplastic Astrocytoma Sequence Alteration SSCP Analysis Include Point Mutation Asymmetric Polymerase Chain Reaction
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