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Detection of p53 Gene Mutations in Human Brain Tumors by Single-strand Conformation Polymorphism Analysis of Polymerase Chain Reaction Products

  • Shoji Mashiyama
  • Takamasa Kayama
  • Ryuichi Katakura
  • Takashi Yoshimoto
  • Yoshinori Murakami
  • Takao Sekiya
  • Kenshi Hayashi

Abstract

The normal (wild-type) p53 product acts as a suppressor of transformation [1], while mutated p53 proteins may inactivate the wild-type p53 function resulting in cell transformation [2]. Mutations of the p53 gene have been found in conjunction with chromosome 17p allelic deletions in many human tumors [3,4].

Keywords

Anaplastic Astrocytoma Sequence Alteration SSCP Analysis Include Point Mutation Asymmetric Polymerase Chain Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Shoji Mashiyama
    • 1
  • Takamasa Kayama
    • 1
  • Ryuichi Katakura
    • 1
  • Takashi Yoshimoto
    • 1
  • Yoshinori Murakami
    • 2
  • Takao Sekiya
    • 2
  • Kenshi Hayashi
    • 2
  1. 1.Division of Neurosurgery, Institute of Brain DiseasesTohoku University School of MedicineSendai, 980Japan
  2. 2.Oncogene DivisionNational Cancer Center Research InstituteChuo-ku, Tokyo, 104Japan

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