Loss of Heterozygosity of Chromosomes 10 and 17 in Human Malignant Astrocytomas
Astrocytomas are the most common tumors of the human central nervous system. Tumors of this type can be classified into four histopathologic grades of malignancy according to Kernohan . Glioblastoma (astrocytoma grade IV) is always lethal despite surgery, radiotherapy, and/or chemotherapy. Low-grade or anaplastic astrocytomas vary in their response to treatment. However, a recurrent tumor is often less well differentiated, suggesting that astrocytoma can be a progressive disease. It is now believed that the genes responsible for tumorigenesis are recessive oncogenes.
KeywordsGlioblastoma Multiforme Anaplastic Astrocytoma Histopathologic Grade Human Central Nervous System Astrocytoma Grade
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