Abstract
Astrocytomas are the most common tumors of the human central nervous system. Tumors of this type can be classified into four histopathologic grades of malignancy according to Kernohan [1]. Glioblastoma (astrocytoma grade IV) is always lethal despite surgery, radiotherapy, and/or chemotherapy. Low-grade or anaplastic astrocytomas vary in their response to treatment. However, a recurrent tumor is often less well differentiated, suggesting that astrocytoma can be a progressive disease. It is now believed that the genes responsible for tumorigenesis are recessive oncogenes.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Zulch, KJ (1979) Histological typing of tumors of the central nervous system. Public Health Pap No. 21
Fults D, Tippets RH, Thomas GA, Nakamura Y, White R (1989) Loss of heterozygosity for loci on chromosome 17p in human malignant astrocytoma. Cancer Res 49: 6572–6577
Baker SJ, Fearon ER, Nigro JM, Hamilton SK, Preisinger AC, Jessup JM, Vantuinen P, Ledbetter DH, Baker DF, Nakamura Y, White R, Vogelstein B (1989) Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244: 217–221
Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P, Glover T, Collins FS, Weston A, Modali R, Harris C, Vogelstein B (1989) Mutations in the p53 gene occur in diverse human tumor types. Nature 342: 705–708
James CD, Carlbom EC, Dumanski JP, Hansen M, Nordenskjold M, Collins VP, Cavenee WK (1988) Clonal genomic alterations in glioma malignancy stages. Cancer Res 48: 5546–5551
El-Azouzi M, Chung RY, Farmer GE, Martuza RL, Black PM, Rouleau GA, Hettlich C, Hedley-White ET, Zervas NT, Panagopoulos K, Nakamura Y, Gusella JF, Seizinger BR (1989) Loss of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas. Proc Natl Acad Sci USA 86: 7186–7190
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Tokyo
About this chapter
Cite this chapter
Tokuda, K. et al. (1991). Loss of Heterozygosity of Chromosomes 10 and 17 in Human Malignant Astrocytomas. In: Tabuchi, K. (eds) Biological Aspects of Brain Tumors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68150-2_40
Download citation
DOI: https://doi.org/10.1007/978-4-431-68150-2_40
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68152-6
Online ISBN: 978-4-431-68150-2
eBook Packages: Springer Book Archive