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Allele Loss on Chromosome 10 in Human Glioblastomas

  • Shuichi Izumoto
  • Norio Arita
  • Takanori Ohnishi
  • Syouju Hiraga
  • Takuyu Taki
  • Masayuki Yamamoto
  • Tetsuro Miki
  • Sin-ichiro Takai
  • Toru Hayakawa

Abstract

Recently, specific chromosomal deletions have been reported to be associated with many human malignancies. It is now thought that loss of constant genetic loci can be taken as evidence of recessive tumor suppressor genes involved in the genesis of human cancers. In this report, allelic deletions on chromosome 10 were studied in human malignant gliomas by using restriction fragment length polymorphisms (RFLPs) analyisis.

Keywords

Anaplastic Astrocytoma Allelic Deletion Human Glioblastoma Multiforme Specific Chromosomal Abnormality Human Malignant Astrocytoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Shuichi Izumoto
    • 1
  • Norio Arita
    • 1
  • Takanori Ohnishi
    • 1
  • Syouju Hiraga
    • 1
  • Takuyu Taki
    • 1
  • Masayuki Yamamoto
    • 2
  • Tetsuro Miki
    • 3
  • Sin-ichiro Takai
    • 4
  • Toru Hayakawa
    • 1
  1. 1.Department of NeurosurgeryOsaka University Medical SchoolOsaka, 553Japan
  2. 2.2nd Department of SurgeryOsaka University Medical SchoolOsaka, 553Japan
  3. 3.Department of Medicine and GeriatricsOsaka University Medical SchoolOsaka, 553Japan
  4. 4.Department of Medical Genetics, Biomedical Research CenterOsaka University Medical SchoolOsaka, 553Japan

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