Electrophoretical Analysis of DNA Topoisomerase I and II Expressions in Human Malignant Gliomas
DNA topoisomerases have been reported to play an important role in DNA replication and transcription . They have been classified into two types of enzyme, topoisomerase I (Topo I) and topoisomerase II (Topo II). Topo I acts on single strand DNA in an adenosine triphosphate (ATP)-independent manner while Topo II acts on double strand DNA in the presence of ATP . Topoisomerases appear to be essential for cell proliferation.
KeywordsMalignant Glioma Johns Hopkins Hospital Nitrogen Mustard Human Malignant Glioma Cleavable Complex
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