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Potentiation of VP-16 Cytotoxicity by Dipyridamole in Malignant Glioma Cells

  • Takanori Ohnishi
  • Hiromitsu Iwasaki
  • Norio Arita
  • Shoju Hiraga
  • Toru Hayakawa

Abstract

VP-16 (etoposide) has been currently used for the treatment of malignant gliomas not only as a chemotherapeutic agent for induction of initial remission but also as a drug for the long-term treatment after remission of the tumors. When VP-16 is used for the latter purpose, however, two major problems should be solved in order to obtain a successful result with this drug. One is to overcome VP-16-resistant cells which may appear in the course of the treatment, and the other is to develop a new mode to treat G0/G1 cells which predominate after intensive treatment of the tumors. These cells make VP-16 cytotoxicity less effective due to the lower amount of DNA topoisomerase II, a target of VP-16 [1].

Keywords

Glioma Cell Malignant Glioma Glioma Cell Line U373MG Cell T98G Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Takanori Ohnishi
  • Hiromitsu Iwasaki
  • Norio Arita
  • Shoju Hiraga
  • Toru Hayakawa
    • 1
  1. 1.Department of NeurosurgeryOsaka University Medical SchoolOsaka, 553Japan

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