Abstract
The platelet-derived growth factor (PDGF) is one of the well known mitogenic factors for glial cells and connective tissue cells [1–3]. It is suggested that PDGF-related protein has an autocrinic effect and participates in malignant neoplastic transformation [4–6]. The mRNA expression of A and B chains was detected in some glioma cells [7]. It was reported that meningiomas expressed both PDGF and its receptor [8]. Expression of the PDGF-related proteins in the various types of brain tumors has not yet been estimated. We have detected 17 kilodalton (kd) PDGF-related proteins in glioma cells [9], and obtained rabbit antibody against glioma-derived PDGF-related protein, with which we studied the presence of PDGF-related proteins in various cultured human cells and brain tumors.
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© 1991 Springer-Verlag Tokyo
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Nakamura, T., Takeshita, I., Fukui, M. (1991). PDGF-Related Proteins in Human Brain Tumors. In: Tabuchi, K. (eds) Biological Aspects of Brain Tumors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68150-2_29
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DOI: https://doi.org/10.1007/978-4-431-68150-2_29
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68152-6
Online ISBN: 978-4-431-68150-2
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