PDGF-Related Proteins in Human Brain Tumors

  • Takaharu Nakamura
  • Iwao Takeshita
  • Masashi Fukui


The platelet-derived growth factor (PDGF) is one of the well known mitogenic factors for glial cells and connective tissue cells [1–3]. It is suggested that PDGF-related protein has an autocrinic effect and participates in malignant neoplastic transformation [4–6]. The mRNA expression of A and B chains was detected in some glioma cells [7]. It was reported that meningiomas expressed both PDGF and its receptor [8]. Expression of the PDGF-related proteins in the various types of brain tumors has not yet been estimated. We have detected 17 kilodalton (kd) PDGF-related proteins in glioma cells [9], and obtained rabbit antibody against glioma-derived PDGF-related protein, with which we studied the presence of PDGF-related proteins in various cultured human cells and brain tumors.


Brain Tumor Glioma Cell U251MG Cell Nonreduced Condition Human Brain Tumor 


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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Takaharu Nakamura
  • Iwao Takeshita
  • Masashi Fukui
    • 1
  1. 1.Department of Neurosurgery, Neurological Institute, Faculty of MedicineKyushu UniversityFukuoka, 812Japan

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