IL-2-Induced Signal Transduction in an Oligodendroglioma Line
Recently, many reports have indicated that glial cells in the central nervous system (CNS) respond to immunoregulatory cytokines [1–3]. Furthermore, it has been shown that some of the cytokines are produced locally in the brain [1,3–5]. The role of interleukin-2 (IL-2) in the CNS has been documented by a number of studies in which IL-2 has been shown to stimulate proliferation of neonatal rat oligodendrocytes and human glioblastoma cell clones at relatively high concentrations (5–50 nM) [6,7]. These observations suggest a potential role of IL-2 in the CNS and raise the issue as to whether the IL-2 signal is transduced in these cells by the same IL-2 receptors (IL-2R) in the immune system.
KeywordsThymidine Incorporation Calcium Phosphate Precipitation Method Transduce Growth Signal Central Nervous System Origin Oligodendroglioma Cell Line
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