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IL-2-Induced Signal Transduction in an Oligodendroglioma Line

  • Yutaka Okamoto
  • Seijiro Minamoto
  • Keiji Shimizu
  • Toru Hayakawa
  • Tadatsugu Taniguchi

Abstract

Recently, many reports have indicated that glial cells in the central nervous system (CNS) respond to immunoregulatory cytokines [1–3]. Furthermore, it has been shown that some of the cytokines are produced locally in the brain [1,3–5]. The role of interleukin-2 (IL-2) in the CNS has been documented by a number of studies in which IL-2 has been shown to stimulate proliferation of neonatal rat oligodendrocytes and human glioblastoma cell clones at relatively high concentrations (5–50 nM) [6,7]. These observations suggest a potential role of IL-2 in the CNS and raise the issue as to whether the IL-2 signal is transduced in these cells by the same IL-2 receptors (IL-2R) in the immune system.

Keywords

Thymidine Incorporation Calcium Phosphate Precipitation Method Transduce Growth Signal Central Nervous System Origin Oligodendroglioma Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Yutaka Okamoto
    • 3
  • Seijiro Minamoto
    • 1
  • Keiji Shimizu
    • 2
  • Toru Hayakawa
    • 2
  • Tadatsugu Taniguchi
    • 1
  1. 1.Institute for Molecular and Cellular BiologyOsaka UniversityOsaka, 565Japan
  2. 2.Department of NeurosurgeryOsaka University Medical SchoolOsaka, 553Japan
  3. 3.Department of NeurosurgeryHanwa Memorial HospitalOsaka, 558Japan

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