Abstract
There are several cytokines and growth factors which are related to the autocrine or paracrine growth of human glioma cells. Platelet-derived growth factor (PDGF) [1], insulin-like growth factor-II (IGF-II) [2], tumor necrosis factor-α (TNF-α), interferon-β (IFN-β) [3], and transforming growth factor-β (TGF-β) [4] have been reported to be synthesized from human glioma cells and released by a variety of forms of induction; they are believed to stimulate or inhibit the growth of glioma cells themselves. On the other hand, IFN and TNF were proved to have a direct anti-proliferative activity against glioma cells in vitro [5–7] and in vivo [5,6], and both cytokines were used clinically for the treatment of patients with malignant glioma [5]. The high dose of 1–3 × 106 IFN-β or of 1–5 × 105 TNF-α is usually administered intravenously, intra-arterially, and/or intrathecally. The results show that a regression of tumor was definitely demonstrated in some cases, although the response rate was not very high, while a reversed progression of tumor was also encountered in a few cases. In order to analyze the mechanism of exogenously added cytokines on growth regulation of human glioma cells, we examined the effect of IFN-β and TNF-α on human glioma cell lines in vitro, and studied the interaction between the growth factors PDGF, IGF-II, and TGF-β.
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© 1991 Springer-Verlag Tokyo
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Yoshida, J., Wakabayashi, T., Mizuno, M., Oyama, H., Nehashi, K., Sugita, K. (1991). The Interaction Between Cytokines and Growth Factors on the Growth of Glioma Cells. In: Tabuchi, K. (eds) Biological Aspects of Brain Tumors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68150-2_25
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DOI: https://doi.org/10.1007/978-4-431-68150-2_25
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68152-6
Online ISBN: 978-4-431-68150-2
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