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The Relationship Between Nucleolar Organizer Regions and Hormone-Producing Activity in Pituitary Adenoma

  • Takashi Matsuhisa
  • Tomohide Maeshiro
  • Minoru Nakagawa
  • Hideaki Shigematsu
  • Kazuyuki Tsuno
  • Kengo Matsumoto
  • Tomohisa Furuta
  • Akira Nishimoto

Abstract

Nucleolar organizer regions (NORs) are loops of DNA which contain ribosomal RNA genes. Recently the number of NORs has been reported to be a marker of histological malignancy [1] or proliferative potential of the tumor cell [2–5]. Fundamentally, however, NORs contribute to protein synthesis. In this study, the relationship between the number or the size of NORs and hormone-producing activity was examined in pituitary adenoma.

Keywords

Pituitary Adenoma Proliferative Potential Nucleolar Organizer Region Silver Nitrate Solution Formic Acid Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Takashi Matsuhisa
  • Tomohide Maeshiro
  • Minoru Nakagawa
  • Hideaki Shigematsu
  • Kazuyuki Tsuno
  • Kengo Matsumoto
  • Tomohisa Furuta
  • Akira Nishimoto
    • 1
  1. 1.Department of Neurological SurgeryOkayama University Medical SchoolOkayama, 700Japan

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