Superoxide Dismutase Activity in Experimental Brain Tumors — Determination by Electron Spin Resonance Spectrometry Using the Spin Trap Method

  • Yukio Ikeda
  • Shozo Nakazawa
  • Masako Yamada


It has been reported that oxygen-free radicals may be related to inflammation, carcinogenesis, immunity, trauma, ischemia, and aging [1]. The mechanisms of the therapeutic effect of radiation and some chemotherapeutic agents may be also mediated by oxygen-free radicals. Radiosensitivity and the cytotoxicity of chemotherapeutic agents are supposed to be associated with the status of endogenous oxygen-free radical scavengers in tumor tissues. A general characteristic of the tumor cell has been reported to be a diminished amount of superoxide dismutase (SOD) coupled with superoxide radical production [2]. We investigated SOD activity in experimental rat brain tumors and normal rat brains by electron spin resonance spectrometry (ESR) with the spin trapping method.


Electron Spin Resonance Brain Tumor Xanthine Oxidase Superoxide Dismutase Activity Subcutaneous Tumor 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Yukio Ikeda
    • 1
  • Shozo Nakazawa
    • 1
  • Masako Yamada
    • 2
  1. 1.Department of NeurosurgeryNippon Medical SchoolBunkyo-ku, Tokyo, 113Japan
  2. 2.ESR Application LaboratoryJEOL Ltd.Akishima-ku, Tokyo, 196Japan

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