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Irradiation Effects on Tumor Blood Flow and Tumor Vascular Permeability in a Rat Transplanted Glioma Model: A Quantitative Autoradiographic Study

  • Shinji Sugimoto
  • Toshimitsu Aida
  • Koichi Tokuda
  • Hiroshi Abe

Abstract

Both radiotherapy and chemotherapy have been mainstays in the treatment of brain tumors. Because the delivery of chemotherapeutic drugs to a brain tumor is currently considered to be dependent upon tumor blood flow and/or tumor vascular permeability, it is important to have a clear understanding of irradiation effects on these transport processes. We report the preliminary results of local blood flow (F) and blood-to-tissue transfer constant (K) measurements with quantitative autoradiography (QAR) in a rat-transplanted glioma model.

Keywords

Brain Tumor Local Blood Flow Transfer Constant Tumor Blood Flow Necrotic Focus 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Shinji Sugimoto
  • Toshimitsu Aida
  • Koichi Tokuda
  • Hiroshi Abe
    • 1
  1. 1.Department of Neurosurgery, School of MedicineHokkaido UniversityKita, Sapporo, 060Japan

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