Metabolic Changes in a Glioma Model Following Chemotherapy
Positron emission tomography (PET) has been widely used in the diagnosis of brain tumors and in the evaluation of therapy. 18F-fiuorodeoxyglucose (18FDG) and 11C-methionine have been used to diagnose the malignancy of tumors and to evaluate therapeutic effectiveness [1–3]. Moreover, tracers indicating the metabolism of nucleic acid have been investigated and 18F-fluoro-2′-deoxyuridine (18FdUrd) was developed for this use [4–8]. To shed light on the metabolic changes in gliomas following therapy, we have used a glioma model to study correlational changes among 18FdUrd, 14C-thymidine, 14C-methionine, and 3H-deoxyglucose uptake after chemotherapy as a means for interpreting clinical PET results, together with the changes in the bromodeoxyuridine labeling index (BUdR LI).
KeywordsPositron Emission Tomography Human Brain Tumor Glioma Model Nucleic Acid Metabolism Cerebral Glioma
Unable to display preview. Download preview PDF.
- 4.Abe Y, Fukuda H, Ishiwata K, Yoshioka S, Yamada K, Endo S, Kubota K, Sato T, Matsuzawa T, Takahashi T, Ido T (1983) Studies on 18F-labeled pyrimidines. Tumor uptakes of 18F-5-fluorouracil, 18F-5-fluorouridine, 18F-5-fluorodeoxy-uridine in animals. Eur J Nucl Med 8: 258–261PubMedCrossRefGoogle Scholar
- 7.Kameyama M, Tsurumi Y, Itoh J, Sato K, Katakura R, Yoshimoto T, Hatazawa J, Itoh M, Ido T (to be published) Clinical application of 18Fluorodeoxyuridine in glioma patients-PET study of nucleic acid metabolism. J Neurol Neurosurg PsychiatryGoogle Scholar
- 11.Ikeda H, Yoshimoto T (to be published) Developmental changes in proliferative activity of cells of the murine Rathke’s pouch. Cell Tissue ResGoogle Scholar
- 18.Hoshino T (1973) Cell kinetics of brain tumors. Neurol Med Chir (Tokyo) 6: 453–459Google Scholar