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Metabolic Changes in a Glioma Model Following Chemotherapy

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Biological Aspects of Brain Tumors

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Abstract

Positron emission tomography (PET) has been widely used in the diagnosis of brain tumors and in the evaluation of therapy. 18F-fiuorodeoxyglucose (18FDG) and 11C-methionine have been used to diagnose the malignancy of tumors and to evaluate therapeutic effectiveness [1–3]. Moreover, tracers indicating the metabolism of nucleic acid have been investigated and 18F-fluoro-2′-deoxyuridine (18FdUrd) was developed for this use [4–8]. To shed light on the metabolic changes in gliomas following therapy, we have used a glioma model to study correlational changes among 18FdUrd, 14C-thymidine, 14C-methionine, and 3H-deoxyglucose uptake after chemotherapy as a means for interpreting clinical PET results, together with the changes in the bromodeoxyuridine labeling index (BUdR LI).

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Authors and Affiliations

  1. Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, 980, Japan

    Kiyotaka Sato, Motonobu Kameyama, Ryuichi Katakura, Takamasa Kayama & Takashi Yoshimoto

  2. Division of Radiopharmaceutical Chemistry, Tohoku University, Sendai, 980, Japan

    Kiichi Ishiwata

Authors
  1. Kiyotaka Sato
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  2. Motonobu Kameyama
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  3. Ryuichi Katakura
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  4. Takamasa Kayama
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  5. Takashi Yoshimoto
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  6. Kiichi Ishiwata
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Saga Medical School, Nabeshima, Saga, 849, Japan

    Kazuo Tabuchi M. D. (Professor and Chairman) (Professor and Chairman)

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© 1991 Springer-Verlag Tokyo

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Sato, K., Kameyama, M., Katakura, R., Kayama, T., Yoshimoto, T., Ishiwata, K. (1991). Metabolic Changes in a Glioma Model Following Chemotherapy. In: Tabuchi, K. (eds) Biological Aspects of Brain Tumors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68150-2_19

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  • DOI: https://doi.org/10.1007/978-4-431-68150-2_19

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68152-6

  • Online ISBN: 978-4-431-68150-2

  • eBook Packages: Springer Book Archive

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