Weibel-Palade Bodies as a Marker for Endothelial Proliferative Potential of Human Glioma Capillaries

  • Shingo Takano
  • Yoshihiko Yoshii
  • Tadao Nose


We studied whether quantitative assessment of Weibel-Palade bodies may represent the proliferative potential of the endothelial cells in human gliomas using the following parameters: histopathological malignancy, blood vessel proliferation, and growth fraction of the endothelial cells.


Endothelial Cell Pituitary Adenoma Glioblastoma Multiforme Human Glioma Anaplastic Astrocytoma 


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  1. 1.
    Weibel ER, Palade GE (1964) New cytoplasmic components in arterial endothelia. J Cell Biol 23: 101–112PubMedCrossRefGoogle Scholar
  2. 2.
    Herrlinger H, Anzil AP, Blinzinger K, Kronski D (1974) Endothelial microtubular bodies in human brain capillaries and venules. J Anat 118: 205–209PubMedGoogle Scholar
  3. 3.
    Miyagami M, Tsubokawa T, Smith BH, Kornblith PL (1985) Tubular bodies ( Weibel-Palade) in the endothelial cell of glioblastoma. No To Shinkei (Brain and Nerve) 37: 277–285Google Scholar
  4. 4.
    Hirano A, Matsui T (1975) Vascular structures in brain tumors. Hum Pathol 6: 611–621PubMedCrossRefGoogle Scholar
  5. 5.
    Kumar P, Kumar S, Marsden HB, Lynch PG, Earnshaw E (1980) Weibel-Palade bodies in endothelial cells as a marker for angiogenesis in brain tumors. Cancer Res 40: 2010–2019PubMedGoogle Scholar
  6. 6.
    Folkman J, Cotran R (1976) Relation of vascular proliferation to tumor growth. Int Rev Exp Path 16: 207–248PubMedGoogle Scholar
  7. 7.
    Schiffer D, Chio A, Giordana T, Mauro A, Migheli A, Vigliani C (1989) The vascular response to tumor infiltration in malignant gliomas. Acta Neuropathol 77: 369–378PubMedCrossRefGoogle Scholar
  8. 8.
    Nagashima T, Hoshino T, Cho KG (1987) Proliferative potential of vascular components in human glioblastoma multiforme. Acta Neuropathol (Berl) 73: 301–305CrossRefGoogle Scholar
  9. 9.
    Brien SE, Zagzag D, Brem S (1989) Rapid in situ cellular kinetics of intracerebral tumor angiogenesis using a monoclonal antibody to bromodeoxyuridine. Neurosurgery 25: 715–719PubMedCrossRefGoogle Scholar
  10. 10.
    Groothuis DR, Fischer JM, Vick NA, Bigner DD (1980) Experimental gliomas: An autoradiographic study of the endothelial component. Neurology 30: 297–301Google Scholar
  11. 11.
    Yoshii Y, Sugiyama K (1988) Intercapillary distance in the proliferating area of human glioma. Cancer Res 48: 2938–2941PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Shingo Takano
  • Yoshihiko Yoshii
  • Tadao Nose
    • 1
  1. 1.Department of Neurological Surgery, Institute of Clinical MedicineUniversity of TsukubaTsukuba, 305Japan

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